HIV entry in the host cell requires the interaction with the CD4 membrane receptor, and depends on the activation of one or both co-receptors CCR5 and CXCR4. Former selective co-receptor antagonists, acting at early stages of infection, are able to impair the receptor functions, preventing the viral spread toward AIDS. Due to the capability of HIV to develop resistance by switching from CCR5 to CXCR4, dual co-receptor antagonists could represent the next generation of AIDS prophylaxis drugs. We herein present a survey on relevant results published in the last few years on compounds acting simultaneously on both co-receptors, potentially useful as preventing agents or in combination with classical anti-retroviral drugs based therapy.

Grande, F., Occhiuzzi, M.a., Rizzuti, B., Ioele, G., De Luca, M., Tucci, P., et al. (2019). CCR5/CXCR4 dual antagonism for the improvement of HIV infection therapy. MOLECULES, 24(3), 550 [10.3390/molecules24030550].

CCR5/CXCR4 dual antagonism for the improvement of HIV infection therapy

Tucci P.;Svicher V.;Aquaro S.;
2019-01-01

Abstract

HIV entry in the host cell requires the interaction with the CD4 membrane receptor, and depends on the activation of one or both co-receptors CCR5 and CXCR4. Former selective co-receptor antagonists, acting at early stages of infection, are able to impair the receptor functions, preventing the viral spread toward AIDS. Due to the capability of HIV to develop resistance by switching from CCR5 to CXCR4, dual co-receptor antagonists could represent the next generation of AIDS prophylaxis drugs. We herein present a survey on relevant results published in the last few years on compounds acting simultaneously on both co-receptors, potentially useful as preventing agents or in combination with classical anti-retroviral drugs based therapy.
2019
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA
English
AIDS; HIV entry; chemokine receptors; dual drugs
Grande, F., Occhiuzzi, M.a., Rizzuti, B., Ioele, G., De Luca, M., Tucci, P., et al. (2019). CCR5/CXCR4 dual antagonism for the improvement of HIV infection therapy. MOLECULES, 24(3), 550 [10.3390/molecules24030550].
Grande, F; Occhiuzzi, Ma; Rizzuti, B; Ioele, G; De Luca, M; Tucci, P; Svicher, V; Aquaro, S; Garofalo, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/210458
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