N-Acetylcysteine (NAC) reduces the risk of exacerbation of chronic obstructive pulmonary disease (COPD). Although NAC also has anti-inflammatory activity, the detailed mechanism leading to its protective role remains to be elucidated. We tested the impact of NAC against the effects of lipopolysaccharide (LPS) in an ex vivo model of COPD exacerbation, and investigated the role of neurokinin A (NKA) in this context.

Calzetta, L., Rogliani, P., Facciolo, F., Rinaldi, B., Cazzola, M., Matera, M.g. (2018). N-Acetylcysteine protects human bronchi by modulating the release of neurokinin A in an ex vivo model of COPD exacerbation. BIOMÉDECINE & PHARMACOTHÉRAPIE, 103, 1-8 [10.1016/j.biopha.2018.04.011].

N-Acetylcysteine protects human bronchi by modulating the release of neurokinin A in an ex vivo model of COPD exacerbation

Calzetta L.;Rogliani P.;Cazzola M.;
2018-01-01

Abstract

N-Acetylcysteine (NAC) reduces the risk of exacerbation of chronic obstructive pulmonary disease (COPD). Although NAC also has anti-inflammatory activity, the detailed mechanism leading to its protective role remains to be elucidated. We tested the impact of NAC against the effects of lipopolysaccharide (LPS) in an ex vivo model of COPD exacerbation, and investigated the role of neurokinin A (NKA) in this context.
2018
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/10 - MALATTIE DELL'APPARATO RESPIRATORIO
English
Con Impact Factor ISI
Anti-inflammatory effect; Anti-oxidant effect; COPD exacerbation; Lipopolysaccharide; N-Acetylcysteine; Acetylcysteine; Biological Availability; Bronchi; Female; Humans; Inflammation; Lipopolysaccharides; Male; Middle Aged; Neurokinin A; Oxidative Stress; Protective Agents; Pulmonary Disease, Chronic Obstructive; Regression Analysis; Disease Progression; Models, Biological
Calzetta, L., Rogliani, P., Facciolo, F., Rinaldi, B., Cazzola, M., Matera, M.g. (2018). N-Acetylcysteine protects human bronchi by modulating the release of neurokinin A in an ex vivo model of COPD exacerbation. BIOMÉDECINE & PHARMACOTHÉRAPIE, 103, 1-8 [10.1016/j.biopha.2018.04.011].
Calzetta, L; Rogliani, P; Facciolo, F; Rinaldi, B; Cazzola, M; Matera, Mg
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/209476
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