The muscarinic receptor response to acetylcholine regulates the hippocampal-related learning, memory, neural plasticity and the production and processing of the pro-nerve growth factor (proNGF) by hippocampal cells. The development and progression of diabetes generate a mild cognitive impairment reducing the functions of the septo-hippocampal cholinergic circuitry, depressing neural plasticity and inducing proNGF accumulation in the brain. Here we demonstrate, in a rat model of early type-1 diabetes, that a physical therapy, the electroacupuncture, counteracts the diabetes-induced deleterious effects on hippocampal physiology by ameliorating hippocampal-related memory functions; recovering the impaired long-term potentiation at the dentate gyrus (DG-LTP) and the lowered expression of the vesicular glutamate transporter 1; normalizing the activity-dependent release of proNGF in diabetic rat hippocampus. Electroacupuncture exerted its therapeutic effects by regulating the expression and activity of M1- and M2-acetylcholine muscarinic receptors subtypes in the dentate gyrus of hippocampus. Our results suggest that a physical therapy based on repetitive sensory stimulation could promote hippocampal neural activity, neuronal metabolism and functions, and conceivably improve the diabetes-induced cognitive impairment. Our data can support the setup of therapeutic protocols based on a better integration between physical therapies and pharmacology for the cure of diabetes-associated neurodegeneration and possibly for Alzheimer's disease.

Soligo, M., Piccinin, S., Protto, V., Gelfo, F., De Stefano, M.e., Florenzano, F., et al. (2017). Recovery of hippocampal functions and modulation of muscarinic response by electroacupuncture in young diabetic rats. SCIENTIFIC REPORTS, 7(1), 9077 [10.1038/s41598-017-08556-z].

Recovery of hippocampal functions and modulation of muscarinic response by electroacupuncture in young diabetic rats

Nisticò, Robert;
2017-08-22

Abstract

The muscarinic receptor response to acetylcholine regulates the hippocampal-related learning, memory, neural plasticity and the production and processing of the pro-nerve growth factor (proNGF) by hippocampal cells. The development and progression of diabetes generate a mild cognitive impairment reducing the functions of the septo-hippocampal cholinergic circuitry, depressing neural plasticity and inducing proNGF accumulation in the brain. Here we demonstrate, in a rat model of early type-1 diabetes, that a physical therapy, the electroacupuncture, counteracts the diabetes-induced deleterious effects on hippocampal physiology by ameliorating hippocampal-related memory functions; recovering the impaired long-term potentiation at the dentate gyrus (DG-LTP) and the lowered expression of the vesicular glutamate transporter 1; normalizing the activity-dependent release of proNGF in diabetic rat hippocampus. Electroacupuncture exerted its therapeutic effects by regulating the expression and activity of M1- and M2-acetylcholine muscarinic receptors subtypes in the dentate gyrus of hippocampus. Our results suggest that a physical therapy based on repetitive sensory stimulation could promote hippocampal neural activity, neuronal metabolism and functions, and conceivably improve the diabetes-induced cognitive impairment. Our data can support the setup of therapeutic protocols based on a better integration between physical therapies and pharmacology for the cure of diabetes-associated neurodegeneration and possibly for Alzheimer's disease.
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Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/14
English
Soligo, M., Piccinin, S., Protto, V., Gelfo, F., De Stefano, M.e., Florenzano, F., et al. (2017). Recovery of hippocampal functions and modulation of muscarinic response by electroacupuncture in young diabetic rats. SCIENTIFIC REPORTS, 7(1), 9077 [10.1038/s41598-017-08556-z].
Soligo, M; Piccinin, S; Protto, V; Gelfo, F; De Stefano, Me; Florenzano, F; Berretta, E; Petrosini, L; Nisticò, R; Manni, L
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Descrizione: Recovery of hippocampal functions and modulation of muscarinic response by electroacupuncture in young diabetic rats
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/207999
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