Several neurodegenerative brain proteinopathies, including Alzheimer's disease (AD), are associated with cerebral deposition of insoluble aggregates of α-synuclein. Previous studies reported a trend toward increased cerebrospinal fluid (CSF) α-synuclein (α-syn) concentrations in AD compared with other neurodegenerative diseases and healthy controls.

Vergallo, A., Bun, R.-., Toschi, N., Baldacci, F., Zetterberg, H., Blennow, K., et al. (2018). Association of cerebrospinal fluid α-synuclein with total and phospho-tau181 protein concentrations and brain amyloid load in cognitively normal subjective memory complainers stratified by Alzheimer's disease biomarkers. ALZHEIMER'S & DEMENTIA, 14(12), 1623-1631 [10.1016/j.jalz.2018.06.3053].

Association of cerebrospinal fluid α-synuclein with total and phospho-tau181 protein concentrations and brain amyloid load in cognitively normal subjective memory complainers stratified by Alzheimer's disease biomarkers

Toschi N.;Floris R.;Garaci F.;
2018-01-01

Abstract

Several neurodegenerative brain proteinopathies, including Alzheimer's disease (AD), are associated with cerebral deposition of insoluble aggregates of α-synuclein. Previous studies reported a trend toward increased cerebrospinal fluid (CSF) α-synuclein (α-syn) concentrations in AD compared with other neurodegenerative diseases and healthy controls.
2018
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/14 - FARMACOLOGIA
English
Alzheimer's disease; Amyloid PET; Cerebrospinal fluid; Monocentric; Preclinical; SUVR; Subjective memory complainers; Synergistic; Tau protein; α-Synuclein
Vergallo, A., Bun, R.-., Toschi, N., Baldacci, F., Zetterberg, H., Blennow, K., et al. (2018). Association of cerebrospinal fluid α-synuclein with total and phospho-tau181 protein concentrations and brain amyloid load in cognitively normal subjective memory complainers stratified by Alzheimer's disease biomarkers. ALZHEIMER'S & DEMENTIA, 14(12), 1623-1631 [10.1016/j.jalz.2018.06.3053].
Vergallo, A; Bun, R-; Toschi, N; Baldacci, F; Zetterberg, H; Blennow, K; Cavedo, E; Lamari, F; Habert, M-; Dubois, B; Floris, R; Garaci, F; Lista, S; Hampel, H
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/207972
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