Alzheimer's disease: understanding homeostasis deregulation to foster development of effective therapies

Alzheimer's disease (AD) is defined as a multifactorial neurodegenerative pathology whose causes resist to researchers even after 112 years of relentless work. Unfortunately, no way has been found yet to cure patients. At best, pharmacotherapy is supportive or palliative. However, the hope is there. After having concentrated all their effort on amyloid plaques and neurofibrillary tangles in the brain or on genetic causes, researchers are trying to reconsider the pathology through different angles. These are based on new modes of investigation that render possible the understanding of multifactorial long progressive pathologies by taking into account the complexity of the biological processes and the compensatory mechanisms induced. These approaches will help to determine the train of events leading to AD and determine key steps on which researchers should focus on. One of the articles in this special issue explains the development of these new technologies and how they open the door to Precision Medicine and Precision Pharmacology approaches, which is of utmost importance to facilitate regulatory approval of forthcoming therapies [1].