Cell-based therapy and regenerative medicine offer a paradigm shift in regard to various diseases causing loss of substance or volume and tissue or organ damage. Recently, many authors have focused their attention on mesenchymal stem cells for their capacity to differentiate into many cell lineages. The most widely studied types are bone marrow mesenchymal stem cells and adipose derived stem cells (ADSCs), which display similar results. Based on the literature, we believe that the ADSCs offer advantages because of lower morbidity during the harvesting procedure. Additionally, platelet-rich plasma can be used in this field for its ability to stimulate tissue regeneration. The aim of this chapter is to describe ADSC preparation and isolation procedures, preparation of platelet-rich plasma, and the application of ADSCs in regenerative plastic surgery. We also discuss the mechanisms and future role of ADSCs in cell-based therapy and tissue engineering.

Gentile, P., Cervelli, V. (2018). Adipose-derived stromal vascular fraction cells and platelet-rich plasma: basic and clinical implications for tissue engineering therapies in regenerative surgery. In B.A. Bunnell, J.M. Gimble (a cura di), Adipose-derived stem cells (pp. 107-122). Springer [10.1007/978-1-4939-7799-4_9].

Adipose-derived stromal vascular fraction cells and platelet-rich plasma: basic and clinical implications for tissue engineering therapies in regenerative surgery

Gentile P.;Cervelli V.
2018

Abstract

Cell-based therapy and regenerative medicine offer a paradigm shift in regard to various diseases causing loss of substance or volume and tissue or organ damage. Recently, many authors have focused their attention on mesenchymal stem cells for their capacity to differentiate into many cell lineages. The most widely studied types are bone marrow mesenchymal stem cells and adipose derived stem cells (ADSCs), which display similar results. Based on the literature, we believe that the ADSCs offer advantages because of lower morbidity during the harvesting procedure. Additionally, platelet-rich plasma can be used in this field for its ability to stimulate tissue regeneration. The aim of this chapter is to describe ADSC preparation and isolation procedures, preparation of platelet-rich plasma, and the application of ADSCs in regenerative plastic surgery. We also discuss the mechanisms and future role of ADSCs in cell-based therapy and tissue engineering.
Settore MED/19 - Chirurgia Plastica
English
Rilevanza internazionale
Capitolo o saggio
Adipose stromal vascular cells; Adipose-derived stem cells; Platelet rich lipotransfert; Platelet-rich plasma
Gentile, P., Cervelli, V. (2018). Adipose-derived stromal vascular fraction cells and platelet-rich plasma: basic and clinical implications for tissue engineering therapies in regenerative surgery. In B.A. Bunnell, J.M. Gimble (a cura di), Adipose-derived stem cells (pp. 107-122). Springer [10.1007/978-1-4939-7799-4_9].
Gentile, P; Cervelli, V
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/207023
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