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EnglishMitochondria are key players in the regulation of T cell biology by dynamically responding to cell needs, but how these dynamics integrate in T cells is still poorly understood. We show here that the mitochondrial pro-fission protein Drp1 fosters migration and expansion of developing thymocytes both in vitro and in vivo. In addition, we find that Drp1 sustains in vitro clonal expansion and cMyc-dependent metabolic reprogramming upon activation, also regulating effector T cell numbers in vivo. Migration and extravasation defects are also exhibited in Drp1-deficient mature T cells, unveiling its crucial role in controlling both T cell recirculation in secondary lymphoid organs and accumulation at tumor sites. Moreover, the observed Drp1-dependent imbalance toward a memory-like phenotype favors T cell exhaustion in the tumor microenvironment. All of these findings support a crucial role for Drp1 in several processes during T cell development and in anti-tumor immune-surveillance.
Simula, L., Pacella, I., Colamatteo, A., Procaccini, C., Cancila, V., Bordi, M., et al. (2018). Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming. CELL REPORTS, 25(11), 3059-3073.e10.
| Tipologia: | Articolo su rivista |
| Citazione: | Simula, L., Pacella, I., Colamatteo, A., Procaccini, C., Cancila, V., Bordi, M., et al. (2018). Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming. CELL REPORTS, 25(11), 3059-3073.e10. |
| Lingua: | English |
| Settore Scientifico Disciplinare: | Settore BIO/06 |
| Revisione (peer review): | Esperti anonimi |
| Tipo: | Articolo |
| Rilevanza: | Rilevanza internazionale |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.celrep.2018.11.018 |
| Stato di pubblicazione: | Pubblicato |
| Data di pubblicazione: | 2018 |
| Titolo: | Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming |
| Autori: | |
| Autori: | Simula, L; Pacella, I; Colamatteo, A; Procaccini, C; Cancila, V; Bordi, M; Tregnago, C; Corrado, M; Pigazzi, M; Barnaba, V; Tripodo, C; Matarese, G; Piconese, S; Campello, S |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| 37 2018 Simula Cell Reports.pdf | N/A | Copyright dell'editore | Open Access Visualizza/Apri |
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