Background: Noncommunicable diseases (NCDs) are the first cause of death worldwide. Mediterranean diet may play a crucial role in the prevention of NCDs, and the presence of wine in this diet could play a positive role on health.Methods: 54 healthy volunteers consumed one of the following beverages: red (RW) or white wine (WW), vodka (VDK), and/or Mediterranean meal (MeDM) and high-fat meal (HFM).Results: OxLDL-C changed significantly between baseline versus HFM, MeDM versus HFM, and HFM versus HFM + RW (p < 0.05). Significant upregulation of catalase (CAT) was observed only after RW. Conversely, WW, VDK, RW + MeDM, HF + WW, and HF + VDK determined a significant downregulation of CAT gene. Superoxide dismutase 2 (SOD2) gene expression was upregulated in WW, MeDM + VDK, and RW. Contrariwise, HFM + VDK determined a downregulation of its expression. RW, RW + MeDM, and RW + HFM caused the upregulation of glutathione peroxidase-1 (GPX1).Conclusions: Our results suggest that the association of low/moderate intake of alcohol beverages, with nutraceutical-proven effectiveness, and ethanol, in association with a Mediterranean diet, could determine a reduction of atherosclerosis risk onset through a positive modulation of antioxidant gene expression helping in the prevention of inflammatory and oxidative damages.

Di Renzo, L., Cioccoloni, G., Sinibaldi Salimei, P., Ceravolo, I., De Lorenzo, A., & Gratteri, S. (2018). Alcoholic Beverage and Meal Choices for the Prevention of Noncommunicable Diseases: A Randomized Nutrigenomic Trial. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2018, 5461436 [10.1155/2018/5461436].

Alcoholic Beverage and Meal Choices for the Prevention of Noncommunicable Diseases: A Randomized Nutrigenomic Trial

Di Renzo, Laura;CIOCCOLONI, GIORGIA;Sinibaldi Salimei, Paola;De Lorenzo, Antonino;
2018

Abstract

Background: Noncommunicable diseases (NCDs) are the first cause of death worldwide. Mediterranean diet may play a crucial role in the prevention of NCDs, and the presence of wine in this diet could play a positive role on health.Methods: 54 healthy volunteers consumed one of the following beverages: red (RW) or white wine (WW), vodka (VDK), and/or Mediterranean meal (MeDM) and high-fat meal (HFM).Results: OxLDL-C changed significantly between baseline versus HFM, MeDM versus HFM, and HFM versus HFM + RW (p < 0.05). Significant upregulation of catalase (CAT) was observed only after RW. Conversely, WW, VDK, RW + MeDM, HF + WW, and HF + VDK determined a significant downregulation of CAT gene. Superoxide dismutase 2 (SOD2) gene expression was upregulated in WW, MeDM + VDK, and RW. Contrariwise, HFM + VDK determined a downregulation of its expression. RW, RW + MeDM, and RW + HFM caused the upregulation of glutathione peroxidase-1 (GPX1).Conclusions: Our results suggest that the association of low/moderate intake of alcohol beverages, with nutraceutical-proven effectiveness, and ethanol, in association with a Mediterranean diet, could determine a reduction of atherosclerosis risk onset through a positive modulation of antioxidant gene expression helping in the prevention of inflammatory and oxidative damages.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/49 - Scienze Tecniche Dietetiche Applicate
English
Con Impact Factor ISI
Adolescent; Adult; Aged; Antioxidants; Catalase; Diet, High-Fat; Diet, Mediterranean; Ethanol; Female; Glutathione Peroxidase; Humans; Lipoproteins, LDL; Male; Middle Aged; Noncommunicable Diseases; Nutrigenomics; Oxidative Stress; Superoxide Dismutase; Young Adult; Alcoholic Beverages; Wine; Biochemistry; Aging; Cell Biology
Di Renzo, L., Cioccoloni, G., Sinibaldi Salimei, P., Ceravolo, I., De Lorenzo, A., & Gratteri, S. (2018). Alcoholic Beverage and Meal Choices for the Prevention of Noncommunicable Diseases: A Randomized Nutrigenomic Trial. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2018, 5461436 [10.1155/2018/5461436].
Di Renzo, L; Cioccoloni, G; Sinibaldi Salimei, P; Ceravolo, I; De Lorenzo, A; Gratteri, S
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/206589
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