Background/Aims: The aim of this study was to investigate whether differences could be detected in genotype and allele frequencies of β-fibrinogen G-455A in relation to recurrent miscarriage (RM). Methods: β-Fibrinogen G-455A polymorphism was investigated by sequencing analysis in 98 women with RM and 78 control women who had no history of miscarriage (controls). Results: The frequency of the -455 A/A genotype of β-fibrinogen was significantly different in women with RM compared with control women. The A/A genotype was found in 8 women of Group 1 (8.2%), but was not detected in any woman of the control group. In contrast, no differences were found in the allele frequencies between RM and control women. Conclusions: Women with the A/A genotype could have an increased risk of RM. However, the allele frequencies were similar between women with recurrent pregnancy loss and control women, suggesting that the effect of β-fibrinogen polymorphisms on RM, if any, is actually very slight.

Ticconi, C., Mancinelli, F., Gravina, P., Federici, G., Piccione, E., Bernardini, S. (2011). Beta-Fibrinogen G-455A Polymorphisms and Recurrent Miscarriage. GYNECOLOGIC AND OBSTETRIC INVESTIGATION, 71(3), 198-201 [10.1159/000317522].

Beta-Fibrinogen G-455A Polymorphisms and Recurrent Miscarriage

TICCONI, CARLO;PICCIONE, EMILIO;BERNARDINI, SERGIO
2011-01-01

Abstract

Background/Aims: The aim of this study was to investigate whether differences could be detected in genotype and allele frequencies of β-fibrinogen G-455A in relation to recurrent miscarriage (RM). Methods: β-Fibrinogen G-455A polymorphism was investigated by sequencing analysis in 98 women with RM and 78 control women who had no history of miscarriage (controls). Results: The frequency of the -455 A/A genotype of β-fibrinogen was significantly different in women with RM compared with control women. The A/A genotype was found in 8 women of Group 1 (8.2%), but was not detected in any woman of the control group. In contrast, no differences were found in the allele frequencies between RM and control women. Conclusions: Women with the A/A genotype could have an increased risk of RM. However, the allele frequencies were similar between women with recurrent pregnancy loss and control women, suggesting that the effect of β-fibrinogen polymorphisms on RM, if any, is actually very slight.
2011
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/40 - GINECOLOGIA E OSTETRICIA
English
Con Impact Factor ISI
Ticconi, C., Mancinelli, F., Gravina, P., Federici, G., Piccione, E., Bernardini, S. (2011). Beta-Fibrinogen G-455A Polymorphisms and Recurrent Miscarriage. GYNECOLOGIC AND OBSTETRIC INVESTIGATION, 71(3), 198-201 [10.1159/000317522].
Ticconi, C; Mancinelli, F; Gravina, P; Federici, G; Piccione, E; Bernardini, S
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/20643
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