Mycobacterium tuberculosis (MTB), the aetiological agent of tuberculosis (TB), is capable of interfering with the phagosome maturation pathway, by inhibiting phagosome-lysosome fusion and the autophagic process to ensure survival and replication in macrophages. Thus, it has been proposed that the modulation of autophagy may represent a therapeutic approach to reduce MTB viability by enhancing its clearance.

Palucci, I., Matic, I., Falasca, L., Minerva, M., Maulucci, G., De Spirito, M., et al. (2018). Transglutaminase type 2 plays a key role in the pathogenesis of Mycobacterium tuberculosis infection. JOURNAL OF INTERNAL MEDICINE, 283(3), 303-313 [10.1111/joim.12714].

Transglutaminase type 2 plays a key role in the pathogenesis of Mycobacterium tuberculosis infection

Matic I.
Writing – Original Draft Preparation
;
Falasca L.;Rossin F.;Piacentini M.
;
2018-03-01

Abstract

Mycobacterium tuberculosis (MTB), the aetiological agent of tuberculosis (TB), is capable of interfering with the phagosome maturation pathway, by inhibiting phagosome-lysosome fusion and the autophagic process to ensure survival and replication in macrophages. Thus, it has been proposed that the modulation of autophagy may represent a therapeutic approach to reduce MTB viability by enhancing its clearance.
mar-2018
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/19 - MICROBIOLOGIA GENERALE
English
Con Impact Factor ISI
LC3; autophagy; cystamine; transglutaminase type 2
Palucci, I., Matic, I., Falasca, L., Minerva, M., Maulucci, G., De Spirito, M., et al. (2018). Transglutaminase type 2 plays a key role in the pathogenesis of Mycobacterium tuberculosis infection. JOURNAL OF INTERNAL MEDICINE, 283(3), 303-313 [10.1111/joim.12714].
Palucci, I; Matic, I; Falasca, L; Minerva, M; Maulucci, G; De Spirito, M; Petruccioli, E; Goletti, D; Rossin, F; Piacentini, M; Delogu, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/206137
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