Mycobacterium tuberculosis (MTB), the aetiological agent of tuberculosis (TB), is capable of interfering with the phagosome maturation pathway, by inhibiting phagosome-lysosome fusion and the autophagic process to ensure survival and replication in macrophages. Thus, it has been proposed that the modulation of autophagy may represent a therapeutic approach to reduce MTB viability by enhancing its clearance.
Palucci, I., Matic, I., Falasca, L., Minerva, M., Maulucci, G., De Spirito, M., et al. (2018). Transglutaminase type 2 plays a key role in the pathogenesis of Mycobacterium tuberculosis infection. JOURNAL OF INTERNAL MEDICINE, 283(3), 303-313 [10.1111/joim.12714].
Transglutaminase type 2 plays a key role in the pathogenesis of Mycobacterium tuberculosis infection
Matic I.Writing – Original Draft Preparation
;Falasca L.;Rossin F.;Piacentini M.
;
2018-03-01
Abstract
Mycobacterium tuberculosis (MTB), the aetiological agent of tuberculosis (TB), is capable of interfering with the phagosome maturation pathway, by inhibiting phagosome-lysosome fusion and the autophagic process to ensure survival and replication in macrophages. Thus, it has been proposed that the modulation of autophagy may represent a therapeutic approach to reduce MTB viability by enhancing its clearance.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
