CINECA IRIS Institutional Research Information System
IRIS è la soluzione IT che facilita la raccolta e la gestione dei dati relativi alle attività e ai prodotti della ricerca. Fornisce a ricercatori, amministratori e valutatori gli strumenti per monitorare i risultati della ricerca, aumentarne la visibilità e allocare in modo efficace le risorse disponibili.
EnglishHIV-1 is characterized by high genetic variability, with implications for spread, and immune-escape selection. Here, the genetic modification of HIV-1 B subtype over time was evaluated on 3,328 pol and 1,152 V3 sequences belonging to B subtype and collected from individuals diagnosed in Italy between 2003 and 2016. Sequences were analyzed for genetic-distance from consensus-B (Tajima-Nei), non-synonymous and synonymous rates (dN and dS), CTL escapes, and intra-host evolution over four time-spans (2003-2006, 2007-2009, 2010-2012, 2013-2016). Genetic-distance increased over time for both pol and V3 sequences (P < 0.0001 and 0.0003). Similar results were obtained for dN and dS. Entropy-value significantly increased at 16 pol and two V3 amino acid positions. Seven of them were CTL escape positions (protease: 71; reverse-transcriptase: 35, 162, 177, 202, 207, 211). Sequences with ≥3 CTL escapes increased from 36.1% in 2003-2006 to 54.0% in 2013-2016 (P < 0.0001), and showed better intra-host adaptation than those containing ≤2 CTL escapes (intra-host evolution: 3.0 × 10-3 [2.9 × 10-3-3.1 × 10-3] vs. 4.3 × 10-3 [4.0 × 10-3-5.0 × 10-3], P[LRT] < 0.0001[21.09]). These data provide evidence of still ongoing modifications, involving CTL escape mutations, in circulating HIV-1 B subtype in Italy. These modifications might affect the process of HIV-1 adaptation to the host, as suggested by the slow intra-host evolution characterizing viruses with a high number of CTL escapes.
Alteri, C., Fabeni, L., Scutari, R., Berno, G., Di Carlo, D., Gori, C., et al. (2018). Genetic divergence of HIV-1 B subtype in Italy over the years 2003–2016 and impact on CTL escape prevalence. SCIENTIFIC REPORTS, 8(1), 15739.
| Tipologia: | Articolo su rivista |
| Citazione: | Alteri, C., Fabeni, L., Scutari, R., Berno, G., Di Carlo, D., Gori, C., et al. (2018). Genetic divergence of HIV-1 B subtype in Italy over the years 2003–2016 and impact on CTL escape prevalence. SCIENTIFIC REPORTS, 8(1), 15739. |
| IF: | Con Impact Factor ISI |
| Lingua: | English |
| Settore Scientifico Disciplinare: | Settore MED/17 - Malattie Infettive Settore MED/07 |
| Revisione (peer review): | Esperti anonimi |
| Tipo: | Articolo |
| Rilevanza: | Rilevanza internazionale |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1038/s41598-018-34058-7 |
| Stato di pubblicazione: | Pubblicato |
| Data di pubblicazione: | 24-ott-2018 |
| Titolo: | Genetic divergence of HIV-1 B subtype in Italy over the years 2003–2016 and impact on CTL escape prevalence |
| Autori: | |
| Autori: | Alteri, C; Fabeni, L; Scutari, R; Berno, G; Di Carlo, D; Gori, C; Bertoli, A; Vergori, A; Mastrorosa, I; Bellagamba, R; Mussini, C; Colafigli, M; Montella, F; Pennica, A; Mastroianni, CM; Girardi, E; Andreoni, M; Antinori, A; Svicher, V; Ceccherini-Silberstein, F; Perno, CF; Santoro, MM |
| Appare nelle tipologie: | 01 - Articolo su rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| 2018_Scientific reports_Alteri_Genetic divergence of HIV-1 B subtype over time.pdf | Versione Editoriale (PDF) | Copyright dell'editore | Open Access Visualizza/Apri |
Copyright © 2021