Correlation between survival and hormonal receptor status in patients with breast cancer is still controversial. The results of a study carried out, from 1973 to 1988, on 55 patients (average age 56.7) affected with breast cancer and submitted to radical (Halsted) mastectomy, are reported. Estradiol receptors (ER) and progesterone receptors (PR) were determined using the dextran-coated charcoal (DCC) method and the enzymatic immuno assay (EIA). The threshold value for defining the ER positivity was 10 f/mole/mg of cytosol protein and 50 f/mole/mg for PR positivity. Forty-one patients resulted as ER+, 31 were also PR+. Moreover, 41 patients were treated with tamoxifen (10 mg x 2 die per os). In a 15-year follow-up, no significant difference in survival rate between patients with receptor-positive tumors or treated with tamoxifen and patients with receptor-negative tumors was recorded.

Buonomo, O., Serao, A., Muggianu, A., Guglielmelli, E., Davoli, E., Amori, A. (1991). Cancer of the breast and the receptor status. IL GIORNALE DI CHIRURGIA, 12(4), 274-277.

Cancer of the breast and the receptor status

Buonomo, O.;
1991-01-01

Abstract

Correlation between survival and hormonal receptor status in patients with breast cancer is still controversial. The results of a study carried out, from 1973 to 1988, on 55 patients (average age 56.7) affected with breast cancer and submitted to radical (Halsted) mastectomy, are reported. Estradiol receptors (ER) and progesterone receptors (PR) were determined using the dextran-coated charcoal (DCC) method and the enzymatic immuno assay (EIA). The threshold value for defining the ER positivity was 10 f/mole/mg of cytosol protein and 50 f/mole/mg for PR positivity. Forty-one patients resulted as ER+, 31 were also PR+. Moreover, 41 patients were treated with tamoxifen (10 mg x 2 die per os). In a 15-year follow-up, no significant difference in survival rate between patients with receptor-positive tumors or treated with tamoxifen and patients with receptor-negative tumors was recorded.
1991
Pubblicato
Rilevanza nazionale
Articolo
Esperti anonimi
Settore MED/18 - CHIRURGIA GENERALE
Italian
Buonomo, O., Serao, A., Muggianu, A., Guglielmelli, E., Davoli, E., Amori, A. (1991). Cancer of the breast and the receptor status. IL GIORNALE DI CHIRURGIA, 12(4), 274-277.
Buonomo, O; Serao, A; Muggianu, A; Guglielmelli, E; Davoli, E; Amori, A
Articolo su rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/204111
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