Male obesity secondary hypogonadism (MOSH) impairs fertility, sexual function, bone mineralization, fat metabolism, cognitive function, deteriorates muscle mass and alters body composition. The aim of this pilot study was to evaluate the effect of dietary intervention and physical activity on the MOSH patient’s hormonal profile after a 10% weight loss compared to baseline. Fourteen male patients were enrolled. Hormonal, lipid, glycemic profiles and body composition were determined at baseline and after a 10% weight loss. Aging Male Symptoms Scale (AMS) and Yale Food Addiction Scale (YFAS) were administered to patients in order to investigate hypogonadal symptoms and food addiction. Compared to baseline, a significant increase of Total Testosterone (TT) (300.2 ± 79.5 ng/dL vs. 408.3 ± 125.9 ng/dL, p = 0.002, 95% CI 26.8; 167.7) and a reduction of 17-Beta Estradiol level (48.3 ± 14.9 pg/mL vs. 39.2 ± 15.2 pg/mL, p = 0.049, 95% CI 3.1; 0.0) were observed. Total Fat Mass (FM) percentage, android and gynoid fat mass percentage (39.2 ± 6.4% vs. 36.2 ± 5.8%, p = 0.0001, 95% CI 22.5; 62.3; 51.5 ± 6.8% vs. 47.6 ± 6.8%, p = 0.001, 95% CI 0.6; 1.8, vs. 39.2 ± 6.2% vs. 36.5 ± 6.3% p = 0.0001, 95% CI 0.9; 2.0 respectively) were significantly decreased after nutritional intervention. In addition, total Fat Free Mass (FFM) in kg was significantly reduced after 10% weight loss (62.3 ± 2.8 kg vs. 60.3 ± 7.7 kg, p = 0.002, 95% CI 45.0; 93.0). Lifestyle changes, specifically dietotherapy and physical activity, induce positive effects on hypogonadism due to obesity.

de Lorenzo, A., Noce, A., Moriconi, E., Rampello, T., Marrone, G., di Daniele, N., et al. (2018). MOSH syndrome (Male obesity secondary hypogonadism): Clinical assessment and possible therapeutic approaches. NUTRIENTS, 10(4), 474 [10.3390/nu10040474].

MOSH syndrome (Male obesity secondary hypogonadism): Clinical assessment and possible therapeutic approaches

de Lorenzo, Antonino;Noce, Annalisa;di Daniele, Nicola;Rovella, Valentina
2018-01-01

Abstract

Male obesity secondary hypogonadism (MOSH) impairs fertility, sexual function, bone mineralization, fat metabolism, cognitive function, deteriorates muscle mass and alters body composition. The aim of this pilot study was to evaluate the effect of dietary intervention and physical activity on the MOSH patient’s hormonal profile after a 10% weight loss compared to baseline. Fourteen male patients were enrolled. Hormonal, lipid, glycemic profiles and body composition were determined at baseline and after a 10% weight loss. Aging Male Symptoms Scale (AMS) and Yale Food Addiction Scale (YFAS) were administered to patients in order to investigate hypogonadal symptoms and food addiction. Compared to baseline, a significant increase of Total Testosterone (TT) (300.2 ± 79.5 ng/dL vs. 408.3 ± 125.9 ng/dL, p = 0.002, 95% CI 26.8; 167.7) and a reduction of 17-Beta Estradiol level (48.3 ± 14.9 pg/mL vs. 39.2 ± 15.2 pg/mL, p = 0.049, 95% CI 3.1; 0.0) were observed. Total Fat Mass (FM) percentage, android and gynoid fat mass percentage (39.2 ± 6.4% vs. 36.2 ± 5.8%, p = 0.0001, 95% CI 22.5; 62.3; 51.5 ± 6.8% vs. 47.6 ± 6.8%, p = 0.001, 95% CI 0.6; 1.8, vs. 39.2 ± 6.2% vs. 36.5 ± 6.3% p = 0.0001, 95% CI 0.9; 2.0 respectively) were significantly decreased after nutritional intervention. In addition, total Fat Free Mass (FFM) in kg was significantly reduced after 10% weight loss (62.3 ± 2.8 kg vs. 60.3 ± 7.7 kg, p = 0.002, 95% CI 45.0; 93.0). Lifestyle changes, specifically dietotherapy and physical activity, induce positive effects on hypogonadism due to obesity.
2018
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/49 - SCIENZE TECNICHE DIETETICHE APPLICATE
English
Con Impact Factor ISI
Aromatase activity; Food addiction; Lifestyle change; MOSH syndrome; Testosterone/ 17-Beta estradiol ratio; Adiposity; Adult; Biomarkers; Estradiol; Eunuchism; Exercise Therapy; Humans; Male; Middle Aged; Nutritional Status; Obesity; Pilot Projects; Risk Reduction Behavior; Rome; Syndrome; Testosterone; Time Factors; Treatment Outcome; Weight Loss; Caloric Restriction; Exercise; Food Science; Nutrition and Dietetics
http://www.mdpi.com/2072-6643/10/4/474/pdf
de Lorenzo, A., Noce, A., Moriconi, E., Rampello, T., Marrone, G., di Daniele, N., et al. (2018). MOSH syndrome (Male obesity secondary hypogonadism): Clinical assessment and possible therapeutic approaches. NUTRIENTS, 10(4), 474 [10.3390/nu10040474].
de Lorenzo, A; Noce, A; Moriconi, E; Rampello, T; Marrone, G; di Daniele, N; Rovella, V
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/203696
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