Triplex nucleic acids have recently attracted interest as part of the rich toolbox of structures used to develop DNA-based nanostructures and materials. This Review addresses the use of DNA triplexes to assemble sensing platforms and molecular switches. Furthermore, the pH-induced, switchable assembly and dissociation of triplex-DNA-bridged nanostructures are presented. Specifically, the aggregation/deaggregation of nanoparticles, the reversible oligomerization of origami tiles and DNA circles, and the use of triplex DNA structures as functional units for the assembly of pH-responsive systems and materials are described. Examples include semiconductor-loaded DNA-stabilized microcapsules, DNA-functionalized dye-loaded metal-organic frameworks (MOFs), and the pH-induced release of the loads. Furthermore, the design of stimuli-responsive DNA-based hydrogels undergoing reversible pH-induced hydrogel-to-solution transitions using triplex nucleic acids is introduced, and the use of triplex DNA to assemble shape-memory hydrogels is discussed. An outlook for possible future applications of triplex nucleic acids is also provided.

Hu, Y., Cecconello, A., Idili, A., Ricci, F., Willner, I. (2017). Triplex DNA Nanostructures: From Basic Properties to Applications. ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, 56(48), 15210-15233 [10.1002/anie.201701868].

Triplex DNA Nanostructures: From Basic Properties to Applications

Idili A.;Ricci F.;
2017-01-01

Abstract

Triplex nucleic acids have recently attracted interest as part of the rich toolbox of structures used to develop DNA-based nanostructures and materials. This Review addresses the use of DNA triplexes to assemble sensing platforms and molecular switches. Furthermore, the pH-induced, switchable assembly and dissociation of triplex-DNA-bridged nanostructures are presented. Specifically, the aggregation/deaggregation of nanoparticles, the reversible oligomerization of origami tiles and DNA circles, and the use of triplex DNA structures as functional units for the assembly of pH-responsive systems and materials are described. Examples include semiconductor-loaded DNA-stabilized microcapsules, DNA-functionalized dye-loaded metal-organic frameworks (MOFs), and the pH-induced release of the loads. Furthermore, the design of stimuli-responsive DNA-based hydrogels undergoing reversible pH-induced hydrogel-to-solution transitions using triplex nucleic acids is introduced, and the use of triplex DNA to assemble shape-memory hydrogels is discussed. An outlook for possible future applications of triplex nucleic acids is also provided.
2017
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore CHIM/01 - CHIMICA ANALITICA
English
DNA triplexes; molecular switches; nanobiotechnology; sensors; stimuli-responsive materials
Hu, Y., Cecconello, A., Idili, A., Ricci, F., Willner, I. (2017). Triplex DNA Nanostructures: From Basic Properties to Applications. ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, 56(48), 15210-15233 [10.1002/anie.201701868].
Hu, Y; Cecconello, A; Idili, A; Ricci, F; Willner, I
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/201221
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