An increased rate of cerebrovascular complications in patients with metabolic syndrome (MetS) has been reported. Previous studies demonstrated an association between glycemic variability (GV) and cerebrovascular reactivity (CRV) in MetS, thus suggesting a putative role of GV on cerebrovascular events. Although the pathophysiological mechanism linking GV to damage is still to be elucidated, evidence suggests oxidative stress plays a crucial role. Since functional variants in glutathione S-transferases (GST) genes modulate the cellular detoxification processes, the aim of this study was to elucidate the involvement of GSTs in MetS and investigating the correlation with GV, arterial stiffness, and sympatho-vagal (SV) balance.

Iorio, A., Ylli, D., Polimanti, R., Picconi, F., Maggio, P., Francomano, D., et al. (2018). Effect of the GSTM1 gene deletion on glycemic variability, sympatho-vagal balance and arterial stiffness in patients with metabolic syndrome, but without diabetes. DIABETES RESEARCH AND CLINICAL PRACTICE, 138, 158-168 [10.1016/j.diabres.2018.02.006].

Effect of the GSTM1 gene deletion on glycemic variability, sympatho-vagal balance and arterial stiffness in patients with metabolic syndrome, but without diabetes

Iorio A.;Ylli D.;Polimanti R.;Picconi F.;Fuciarelli M.;Frontoni S.
2018-04-01

Abstract

An increased rate of cerebrovascular complications in patients with metabolic syndrome (MetS) has been reported. Previous studies demonstrated an association between glycemic variability (GV) and cerebrovascular reactivity (CRV) in MetS, thus suggesting a putative role of GV on cerebrovascular events. Although the pathophysiological mechanism linking GV to damage is still to be elucidated, evidence suggests oxidative stress plays a crucial role. Since functional variants in glutathione S-transferases (GST) genes modulate the cellular detoxification processes, the aim of this study was to elucidate the involvement of GSTs in MetS and investigating the correlation with GV, arterial stiffness, and sympatho-vagal (SV) balance.
apr-2018
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/13 - ENDOCRINOLOGIA
English
AMP-activated protein kinase; Autonomic function; Genetic polymorphisms; Glucose excursions; Metabolic syndrome; Adult; Aged; Aged, 80 and over; Blood Glucose; Case-Control Studies; Female; Glutathione Transferase; Humans; Male; Metabolic Syndrome; Middle Aged; Polymorphism, Genetic; Vascular Stiffness; Gene Deletion
Iorio, A., Ylli, D., Polimanti, R., Picconi, F., Maggio, P., Francomano, D., et al. (2018). Effect of the GSTM1 gene deletion on glycemic variability, sympatho-vagal balance and arterial stiffness in patients with metabolic syndrome, but without diabetes. DIABETES RESEARCH AND CLINICAL PRACTICE, 138, 158-168 [10.1016/j.diabres.2018.02.006].
Iorio, A; Ylli, D; Polimanti, R; Picconi, F; Maggio, P; Francomano, D; Aversa, A; Manfellotto, D; Fuciarelli, M; Frontoni, S
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/200742
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 3
  • ???jsp.display-item.citation.isi??? 1
social impact