Vitamin D is a fat-soluble vitamin and a steroid hormone that plays a central role in maintaining calcium-phosphorus and bone homeostasis in close interaction with parathyroid hormone, acting on its classical target tissues, namely, bone, kidney, intestine, and parathyroid glands. However, vitamin D endocrine system regulates several genes (about 3 % of the human genome) involved in cell differentiation, cell-cycle control, and cell function and exerts noncalcemic/pleiotropic effects on extraskeletal target tissues, such as immune and cardiovascular system, pancreatic endocrine cells, muscle, and adipose tissue. Several studies have demonstrated the role of vitamin D supplementation in the prevention/treatment of various autoimmune diseases and improvement of glucose metabolism, muscle, and adipose tissue function. Hence, this review aims to elucidate the effects of vitamin D on extraskeletal target tissues and to investigate the potential therapeutic benefit of vitamin D supplementation among a broad group of pathological conditions, especially with regard to metabolic and autoimmune diseases. In addition, we focused on the best daily intakes and serum levels of vitamin D required for extraskeletal benefits which, even if still controversial, appear to be higher than those widely accepted for skeletal effects.

Caprio, M., Infante, M., Calanchini, M., Mammi, C., & Fabbri, A. (2017). Vitamin D: not just the bone. Evidence for beneficial pleiotropic extraskeletal effects. EATING AND WEIGHT DISORDERS, 22(1), 27-41 [10.1007/s40519-016-0312-6].

Vitamin D: not just the bone. Evidence for beneficial pleiotropic extraskeletal effects

CAPRIO, MASSIMILIANO;FABBRI, ANDREA
2017

Abstract

Vitamin D is a fat-soluble vitamin and a steroid hormone that plays a central role in maintaining calcium-phosphorus and bone homeostasis in close interaction with parathyroid hormone, acting on its classical target tissues, namely, bone, kidney, intestine, and parathyroid glands. However, vitamin D endocrine system regulates several genes (about 3 % of the human genome) involved in cell differentiation, cell-cycle control, and cell function and exerts noncalcemic/pleiotropic effects on extraskeletal target tissues, such as immune and cardiovascular system, pancreatic endocrine cells, muscle, and adipose tissue. Several studies have demonstrated the role of vitamin D supplementation in the prevention/treatment of various autoimmune diseases and improvement of glucose metabolism, muscle, and adipose tissue function. Hence, this review aims to elucidate the effects of vitamin D on extraskeletal target tissues and to investigate the potential therapeutic benefit of vitamin D supplementation among a broad group of pathological conditions, especially with regard to metabolic and autoimmune diseases. In addition, we focused on the best daily intakes and serum levels of vitamin D required for extraskeletal benefits which, even if still controversial, appear to be higher than those widely accepted for skeletal effects.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/13 - Endocrinologia
English
Con Impact Factor ISI
Adipose tissue; Anorexia nervosa; Autoimmune diseases; Diabetes; Eating disorders; Glucose metabolism; Hashimoto thyroiditis; Multiple sclerosis; Obesity; Skeletal muscle
Caprio, M., Infante, M., Calanchini, M., Mammi, C., & Fabbri, A. (2017). Vitamin D: not just the bone. Evidence for beneficial pleiotropic extraskeletal effects. EATING AND WEIGHT DISORDERS, 22(1), 27-41 [10.1007/s40519-016-0312-6].
Caprio, M; Infante, M; Calanchini, M; Mammi, C; Fabbri, A
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/198188
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