In addition to the well-documented expression and activity of the mineralocorticoid receptor (MR) in the kidney, in the last decade research on MR has also revealed its important role in regulating functions of extrarenal tissues, including adipose tissue, where MR is involved in adipocyte fundamental processes such as differentiation, autophagy and adipokine secretion. MR expression is increased in adipose tissue of murine models of obesity and in obese human subjects, suggesting that over-activation of the mineralocorticoid signaling leads to dysfunctional adipocyte and associated metabolic disorders. Notably, pharmacological blockade of MR prevents metabolic dysfunctions observed in obese mice and suggests a potential therapeutic use of MR antagonists in the treatment of obesity and metabolic syndrome. However, the molecular pathways affected by MR blockade have been poorly investigated. This review summarizes the functions of MR in the adipocyte, discusses potential signaling pathways mediating MR action, and describes post-translational modifications regulating its activity.

Armani, A., Marzolla, V., Fabbri, A., & Caprio, M. (2015). Cellular mechanisms of MR regulation of adipose tissue physiology and pathophysiology. JOURNAL OF MOLECULAR ENDOCRINOLOGY, 55(2), R1-R10 [10.1530/JME-15-0122].

Cellular mechanisms of MR regulation of adipose tissue physiology and pathophysiology

FABBRI, ANDREA;
2015

Abstract

In addition to the well-documented expression and activity of the mineralocorticoid receptor (MR) in the kidney, in the last decade research on MR has also revealed its important role in regulating functions of extrarenal tissues, including adipose tissue, where MR is involved in adipocyte fundamental processes such as differentiation, autophagy and adipokine secretion. MR expression is increased in adipose tissue of murine models of obesity and in obese human subjects, suggesting that over-activation of the mineralocorticoid signaling leads to dysfunctional adipocyte and associated metabolic disorders. Notably, pharmacological blockade of MR prevents metabolic dysfunctions observed in obese mice and suggests a potential therapeutic use of MR antagonists in the treatment of obesity and metabolic syndrome. However, the molecular pathways affected by MR blockade have been poorly investigated. This review summarizes the functions of MR in the adipocyte, discusses potential signaling pathways mediating MR action, and describes post-translational modifications regulating its activity.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/13 - Endocrinologia
English
Con Impact Factor ISI
insulin signaling; metabolism; obesity; steroid hormones; Adipocytes; Adipogenesis; Adipose Tissue; Animals; Autophagy; Inflammation; Metabolic Syndrome X; Mice; Mineralocorticoid Receptor Antagonists; Obesity; Protein Processing, Post-Translational; Receptors, Mineralocorticoid; Signal Transduction; Transcription, Genetic
Armani, A., Marzolla, V., Fabbri, A., & Caprio, M. (2015). Cellular mechanisms of MR regulation of adipose tissue physiology and pathophysiology. JOURNAL OF MOLECULAR ENDOCRINOLOGY, 55(2), R1-R10 [10.1530/JME-15-0122].
Armani, A; Marzolla, V; Fabbri, A; Caprio, M
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/198182
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