Elevated aldosterone is associated with increased risk of atherosclerosis complications, whereas treatment with mineralocorticoid receptor (MR) antagonists decreases the rate of cardiovascular events. Here we test the hypothesis that aldosterone promotes early atherosclerosis by modulating intercellular adhesion molecule-1 (ICAM-1) expression and investigate the molecular mechanisms by which aldosterone regulates ICAM-1 expression.

Marzolla, V., Armani, A., Mammi, C., Moss, M., Pagliarini, V., Pontecorvo, L., et al. (2017). Essential role of ICAM-1 in aldosterone-induced atherosclerosis. INTERNATIONAL JOURNAL OF CARDIOLOGY, 232, 233-242 [10.1016/j.ijcard.2017.01.013].

Essential role of ICAM-1 in aldosterone-induced atherosclerosis

PAGLIARINI, VITTORIA;FABBRI, ANDREA;CAPRIO, MASSIMILIANO
2017

Abstract

Elevated aldosterone is associated with increased risk of atherosclerosis complications, whereas treatment with mineralocorticoid receptor (MR) antagonists decreases the rate of cardiovascular events. Here we test the hypothesis that aldosterone promotes early atherosclerosis by modulating intercellular adhesion molecule-1 (ICAM-1) expression and investigate the molecular mechanisms by which aldosterone regulates ICAM-1 expression.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/13 - Endocrinologia
English
Con Impact Factor ISI
Aldosterone; Atherosclerosis; Endothelial cells; Intercellular adhesion molecule-1; Mineralocorticoid receptor
Marzolla, V., Armani, A., Mammi, C., Moss, M., Pagliarini, V., Pontecorvo, L., et al. (2017). Essential role of ICAM-1 in aldosterone-induced atherosclerosis. INTERNATIONAL JOURNAL OF CARDIOLOGY, 232, 233-242 [10.1016/j.ijcard.2017.01.013].
Marzolla, V; Armani, A; Mammi, C; Moss, M; Pagliarini, V; Pontecorvo, L; Antelmi, A; Fabbri, A; Rosano, G; Jaffe, I; Caprio, M
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/198180
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