In vivo and in vitro experiments have shown that processing of ribosomal RNA is a late event in ribosome biogenesis. The precursor form of RNA is probably necessary to speed up the assembly of ribomal proteins. Newly formed ribosomal particles which have already entered polyribosomes differ from mature ribosomes not only in their RNA content but also in their susceptibility to unfolding in low Mg concentration and to RNase attack. Final maturation of new ribosomes is probably dependent on their functioning in protein synthesis. Thus only those ribosomes which have proven to be functional may be converted into stable cellular structures.

Silengo, L., Altruda, F., Dotto, G., Lacquaniti, F., Perlo, C., Turco, E., et al. (1977). Ribosome maturation in E. coli. ITALIAN JOURNAL OF BIOCHEMISTRY, 26(2), 133-143.

Ribosome maturation in E. coli

LACQUANITI, FRANCESCO;
1977

Abstract

In vivo and in vitro experiments have shown that processing of ribosomal RNA is a late event in ribosome biogenesis. The precursor form of RNA is probably necessary to speed up the assembly of ribomal proteins. Newly formed ribosomal particles which have already entered polyribosomes differ from mature ribosomes not only in their RNA content but also in their susceptibility to unfolding in low Mg concentration and to RNase attack. Final maturation of new ribosomes is probably dependent on their functioning in protein synthesis. Thus only those ribosomes which have proven to be functional may be converted into stable cellular structures.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/09
English
Con Impact Factor ISI
Polyribosomes; time factors; ribosomal proteins; rna, ribosomal; escherichia coli; ribosomes; neomycin
Silengo, L., Altruda, F., Dotto, G., Lacquaniti, F., Perlo, C., Turco, E., et al. (1977). Ribosome maturation in E. coli. ITALIAN JOURNAL OF BIOCHEMISTRY, 26(2), 133-143.
Silengo, L; Altruda, F; Dotto, G; Lacquaniti, F; Perlo, C; Turco, E; Mangiarotti, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/19705
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