Sickle cell anemia (SCA) and β -thalassemia major are well-recognized beta-globin gene disorders of red blood cells associated to mortality and morbidity included bone morbidities due to ineffective erythropoiesis and bone marrow expansion, which affect every part of the skeleton. While there are an abundance of described disease manifestations of the head and neck, the manner of paranasal sinuses involvement and its relations to β-thalassemia and SCA process was not studied yet. Therefore, the aim of this study was to investigate a possible increased risk of rhinosinusitis and the real pathogenetic mechanism of it, comparing these two hematological diseases using msCT, gold standard for paranasal sinuses evaluation.

Martino, F., Di Mauro, R., Paciaroni, K., Gaziev, J., Alfieri, C., Greco, L., et al. (2018). Pathogenesis of chronic rhinosinusitis in patients affected by β-thalassemia major and sickle cell anaemia post allogenic bone marrow transplant. INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, 106, 35-40 [10.1016/j.ijporl.2018.01.002].

Pathogenesis of chronic rhinosinusitis in patients affected by β-thalassemia major and sickle cell anaemia post allogenic bone marrow transplant

Floris, R;Di Girolamo, S;Di Girolamo, M
2018-03-01

Abstract

Sickle cell anemia (SCA) and β -thalassemia major are well-recognized beta-globin gene disorders of red blood cells associated to mortality and morbidity included bone morbidities due to ineffective erythropoiesis and bone marrow expansion, which affect every part of the skeleton. While there are an abundance of described disease manifestations of the head and neck, the manner of paranasal sinuses involvement and its relations to β-thalassemia and SCA process was not studied yet. Therefore, the aim of this study was to investigate a possible increased risk of rhinosinusitis and the real pathogenetic mechanism of it, comparing these two hematological diseases using msCT, gold standard for paranasal sinuses evaluation.
mar-2018
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/31 - OTORINOLARINGOIATRIA
English
CT; Maxillary sinus; Sickle cell anemia; Sinusitis; Thalassemia; Adolescent; Anemia, Sickle Cell; Bone Marrow Transplantation; Child; Child, Preschool; Chronic Disease; Female; Humans; Male; Retrospective Studies; Rhinitis; Risk Assessment; Sinusitis; Tomography, X-Ray Computed; Young Adult; beta-Thalassemia
Martino, F., Di Mauro, R., Paciaroni, K., Gaziev, J., Alfieri, C., Greco, L., et al. (2018). Pathogenesis of chronic rhinosinusitis in patients affected by β-thalassemia major and sickle cell anaemia post allogenic bone marrow transplant. INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, 106, 35-40 [10.1016/j.ijporl.2018.01.002].
Martino, F; Di Mauro, R; Paciaroni, K; Gaziev, J; Alfieri, C; Greco, L; Floris, R; Di Girolamo, S; Di Girolamo, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/196089
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