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In this study, we analysed in a cohort of pregnant women followed for 2 years, the proportion of women remaining followed at the site, of those transferred to other clinics and of those lost to follow-up. The possible determinants of the loss to follow-up were also assessed in a setting of postpartum discontinuation based on CD4+ count. A total of 311 pregnant women received antiretroviral therapy from week 25 of gestational age until 6 months postpartum (end of breastfeeding period), or indefinitely if meeting the criteria for treatment (baseline CD4+ <350/mm(3)). Twenty-four months after delivery six women had died, 247 were in active follow-up, 21 had transferred to another antiretroviral therapy clinic and 37 were lost to follow-up (rate of loss to follow-up 13%, 95% CI 9.1-16.9%). The presence of a baseline CD4+ count above 350/mm(3) was associated with a 10-fold higher risk of loss to follow-up after 6 months of delivery (hazard ratio: 9.8, 95% CI 2.2-42.7, for baseline CD4 >350/mm(3) versus baseline CD4+ count below 350/mm(3), p = 0.002). This finding suggests that discontinuation of drugs when the risk of transmission is ceased can have a negative impact on the retention in care of these women.

Giuliano, M., LIOTTA, G., Andreotti, M., MANCINELLI, S., BUONOMO, E., SCARCELLA, P., et al. (2016). Retention, transfer out and loss to follow-up 2 years after delivery in a cohort of HIV+ pregnant women in Malawi. INTERNATIONAL JOURNAL OF STD & AIDS, 27(6), 462-468.

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