Background HIV-exposed uninfected children have a higher risk of infection and mortality compared to HIV-unexposed children and the reasons for this vulnerability are still under investigation. Aim: This study aimed to evaluate the influence of maternal HIV parameters on the passive transfer of anti-pneumococcal capsular polysaccharide (PCP) IgG and to determine whether the concentrations of specific IgG might be related to the morbidity and mortality in HIV-exposed uninfected children. Methods One hundred and twenty-six Malawian HIV-infected pregnant women and their uninfected children were studied. Antiretroviral treatment-naive women started a nevirapine-based triple combination regimen from the third trimester of pregnancy until at least 6 months of exclusive breastfeeding. Mother/child pairs were followed until 2 years after delivery. Plasma anti-PCP IgG titers (in mothers at 26 weeks of gestation and in infants at 1 and 6 months) were determined by an enzyme-linked immunosorbent assay. None of these women and children had received any vaccination against pneumococcal polysaccharides. Results Maternal anti-PCP IgG concentration was independent from viral load (p = 0.848), CD4 count (p = 0.740) and WHO stage (p = 0.450). However, the child/mother ratio of anti-PCP IgG measured at 1 month among infants was significantly reduced in pairs whose mothers had HIV-RNA > 10 000 copies/ml (p = 0.043) and CD4 < 350 cells/μl (p = 0.090) before antiretroviral therapy (ART). No clear associations between anti-PCP IgG and respiratory-related deaths were found, but respiratory infection episodes were more frequent among children with lower anti-PCP IgG ratio (p = 0.046). Conclusion This study indicates that HIV pre-ART conditions in mothers may influence the rate of specific immunoglobulins transfer, increasing infants vulnerability to respiratory infections.
Baroncelli, S., Galluzzo, C., MANCINELLI, S., Andreotti, M., Jere, H., Amici, R., et al. (2015). Antibodies against pneumococcal capsular polysaccharide in Malawian HIV-positive mothers and their HIV-exposed uninfected children. INFECTIOUS DISEASES, 48(4), 317-321.
|Tipologia:||Articolo su rivista|
|Citazione:||Baroncelli, S., Galluzzo, C., MANCINELLI, S., Andreotti, M., Jere, H., Amici, R., et al. (2015). Antibodies against pneumococcal capsular polysaccharide in Malawian HIV-positive mothers and their HIV-exposed uninfected children. INFECTIOUS DISEASES, 48(4), 317-321.|
|Altre informazioni significative:||Infect Dis (Lond). 2015 Nov 26:1-5. [Epub ahead of print]|
|IF:||Con Impact Factor ISI|
|Settore Scientifico Disciplinare:||Settore MED/42 - Igiene Generale e Applicata|
|Revisione (peer review):||Esperti anonimi|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3109/23744235.2015.1115895|
|Stato di pubblicazione:||Online ahead of print|
|Data di pubblicazione:||26-nov-2015|
|Titolo:||Antibodies against pneumococcal capsular polysaccharide in Malawian HIV-positive mothers and their HIV-exposed uninfected children|
|Autori:||Baroncelli, S; Galluzzo, C; MANCINELLI, S; Andreotti, M; Jere, H; Amici, R; Marazzi, M; Vella, S; PALOMBI, L; Giuliano, M|
|Appare nelle tipologie:||01 - Articolo su rivista|
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