The aim of this study was to assess the immune response to HBV vaccine in HIV-exposed infants and to correlate it to HBV infection acquisition. Protective anti-HBs levels (>10 mIU/mL) were found in 54/58 (93.2%) infants at 6 months, 126/144 (87.5%) at 12 months and 141/176 (80.1%) children at 24 months. HBV infection (seven children were HBsAg + at Month 24) occurred also in the presence of levels above 10 mIU/mL. Our findings indicate limited impact of HIV exposure on anti-HBV immune response, but suggest that levels >10 mIU/mL may be required to confer protection in this context.

Mancinelli, S., Pirillo, M.F., Liotta, G., Andreotti, M., Mphwere, R., Amici, R., et al. (2018). Antibody response to hepatitis B vaccine in HIV-exposed infants in Malawi and correlation with HBV infection acquisition. JOURNAL OF MEDICAL VIROLOGY, 90(6), 1172-1176 [10.1002/jmv.25049].

Antibody response to hepatitis B vaccine in HIV-exposed infants in Malawi and correlation with HBV infection acquisition

Mancinelli S.;Liotta G.;Palombi L.;
2018

Abstract

The aim of this study was to assess the immune response to HBV vaccine in HIV-exposed infants and to correlate it to HBV infection acquisition. Protective anti-HBs levels (>10 mIU/mL) were found in 54/58 (93.2%) infants at 6 months, 126/144 (87.5%) at 12 months and 141/176 (80.1%) children at 24 months. HBV infection (seven children were HBsAg + at Month 24) occurred also in the presence of levels above 10 mIU/mL. Our findings indicate limited impact of HIV exposure on anti-HBV immune response, but suggest that levels >10 mIU/mL may be required to confer protection in this context.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/42 - Igiene Generale e Applicata
Settore MED/17 - Malattie Infettive
Settore MED/09 - Medicina Interna
English
Con Impact Factor ISI
HBV; HBV vaccine; HIV-exposed infants; sub-Saharan Africa
http://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=2&SID=E6qb6HBd8OwXf5ojtV9&page=1&doc=1
Mancinelli, S., Pirillo, M.F., Liotta, G., Andreotti, M., Mphwere, R., Amici, R., et al. (2018). Antibody response to hepatitis B vaccine in HIV-exposed infants in Malawi and correlation with HBV infection acquisition. JOURNAL OF MEDICAL VIROLOGY, 90(6), 1172-1176 [10.1002/jmv.25049].
Mancinelli, S; Pirillo, Mf; Liotta, G; Andreotti, M; Mphwere, R; Amici, R; Marazzi, Mc; Vella, S; Palombi, L; Giuliano, M
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/195400
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