A simple approach is reported to engineer biodegradable and biocompatible nanoporous hyaluronic acid particles (NPHAs) with a characteristic spongelike morphology and uniform size. These NPHAs can be synthesized using the concomitant cross-linking of hyaluronic acid and the cross-linking agent precipitation. The nanoporous architecture of NPHAs prevents the rapid enzymatic degradation of hyaluronic acid and controls the erosion of microparticles in physiological conditions. Once injected into an intra-articular body cavity of healthy mice, these NPHAs reside at the point-of-delivery for an extended time period, exhibiting a sustained release of hyaluronic acid. In addition, in vivo studies indicate the persistence of NPHAs in the knee joints with neither accumulation into major organs, nor any local or systemic side-effect. The use of NPHAs is emphasized as reservoirs of hyaluronic acid, effectively providing an innovative and safe platform for prolonging the favorable effects displayed by hyaluronic acid on joints affected by osteoarthritis.

Palmieri, G., Rinaldi, A., Campagnolo, L., Tortora, M., Caso, M.f., Mattei, M., et al. (2017). Hyaluronic acid nanoporous microparticles with long in vivo joint residence time and sustained release. PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION, 34(6), 1600411 [10.1002/ppsc.201600411].

Hyaluronic acid nanoporous microparticles with long in vivo joint residence time and sustained release

Palmieri G.;Campagnolo L.;Tortora M.;Mattei M.;Rosato N.;Bottini M.
;
Cavalieri F.
2017

Abstract

A simple approach is reported to engineer biodegradable and biocompatible nanoporous hyaluronic acid particles (NPHAs) with a characteristic spongelike morphology and uniform size. These NPHAs can be synthesized using the concomitant cross-linking of hyaluronic acid and the cross-linking agent precipitation. The nanoporous architecture of NPHAs prevents the rapid enzymatic degradation of hyaluronic acid and controls the erosion of microparticles in physiological conditions. Once injected into an intra-articular body cavity of healthy mice, these NPHAs reside at the point-of-delivery for an extended time period, exhibiting a sustained release of hyaluronic acid. In addition, in vivo studies indicate the persistence of NPHAs in the knee joints with neither accumulation into major organs, nor any local or systemic side-effect. The use of NPHAs is emphasized as reservoirs of hyaluronic acid, effectively providing an innovative and safe platform for prolonging the favorable effects displayed by hyaluronic acid on joints affected by osteoarthritis.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/10
English
Con Impact Factor ISI
https://onlinelibrary.wiley.com/doi/abs/10.1002/ppsc.201600411
Palmieri, G., Rinaldi, A., Campagnolo, L., Tortora, M., Caso, M.f., Mattei, M., et al. (2017). Hyaluronic acid nanoporous microparticles with long in vivo joint residence time and sustained release. PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION, 34(6), 1600411 [10.1002/ppsc.201600411].
Palmieri, G; Rinaldi, A; Campagnolo, L; Tortora, M; Caso, Mf; Mattei, M; Notargiacomo, A; Rosato, N; Bottini, M; Cavalieri, F
Articolo su rivista
File in questo prodotto:
File Dimensione Formato  
Particle & Particle Systems Characterization.pdf

non disponibili

Licenza: Copyright dell'editore
Dimensione 1.39 MB
Formato Adobe PDF
1.39 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/194755
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 7
social impact