Although overexpression of the brain and acute leukemia, cytoplasmic (BAALC) gene is associated with primary resistant disease and shorter relapse-free, disease-free, and overall survival in different subsets of acute myeloid leukemia (AML), little is known about its clinical impact in acute promyelocytic leukemia (APL). Using real-time reverse transcriptase polymerase chain reaction, we showed thatBAALCexpression is significantly lower in APL compared with other subsets of AML (P< .001). We also demonstrated thatBAALCoverexpression was associated with shorter disease-free survival (DFS) (hazard ratio [HR], 4.43; 95% confidence interval [CI], 1.29-15.2;P= .018) in 221 consecutive patients (median age, 35 years; range, 18-82 years) with newly diagnosed APL homogeneously treated with all-transretinoic acid and anthracycline-based chemotherapy. Cox proportional hazard modeling showed thatBAALCoverexpression was independently associated with shorter DFS in the total cohort (HR, 5.26; 95% CI, 1.52-18.2;P= .009) and in patients with high-risk disease (ie, those with initial leukocyte counts >10 × 109/L) (HR, 5.3; 95% CI, 1.14-24.5;P= .033). We conclude thatBAALCexpression could be useful for refining risk stratification in APL, although this needs to be confirmed in independent cohorts.

Lucena-Araujo, A.r., Pereira-Martins, D.a., Koury, L.c., Franca-Neto, P.l., Coelho-Silva, J.l., de Deus Wagatsuma, V.m., et al. (2017). Clinical impact ofBAALCexpression in high-risk acute promyelocytic leukemia. BLOOD ADVANCES, 1(21), 1807-1814 [10.1182/bloodadvances.2017005926].

Clinical impact ofBAALCexpression in high-risk acute promyelocytic leukemia

Lo-Coco, Francesco;
2017-09-26

Abstract

Although overexpression of the brain and acute leukemia, cytoplasmic (BAALC) gene is associated with primary resistant disease and shorter relapse-free, disease-free, and overall survival in different subsets of acute myeloid leukemia (AML), little is known about its clinical impact in acute promyelocytic leukemia (APL). Using real-time reverse transcriptase polymerase chain reaction, we showed thatBAALCexpression is significantly lower in APL compared with other subsets of AML (P< .001). We also demonstrated thatBAALCoverexpression was associated with shorter disease-free survival (DFS) (hazard ratio [HR], 4.43; 95% confidence interval [CI], 1.29-15.2;P= .018) in 221 consecutive patients (median age, 35 years; range, 18-82 years) with newly diagnosed APL homogeneously treated with all-transretinoic acid and anthracycline-based chemotherapy. Cox proportional hazard modeling showed thatBAALCoverexpression was independently associated with shorter DFS in the total cohort (HR, 5.26; 95% CI, 1.52-18.2;P= .009) and in patients with high-risk disease (ie, those with initial leukocyte counts >10 × 109/L) (HR, 5.3; 95% CI, 1.14-24.5;P= .033). We conclude thatBAALCexpression could be useful for refining risk stratification in APL, although this needs to be confirmed in independent cohorts.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/15 - Malattie del Sangue
English
Lucena-Araujo, A.r., Pereira-Martins, D.a., Koury, L.c., Franca-Neto, P.l., Coelho-Silva, J.l., de Deus Wagatsuma, V.m., et al. (2017). Clinical impact ofBAALCexpression in high-risk acute promyelocytic leukemia. BLOOD ADVANCES, 1(21), 1807-1814 [10.1182/bloodadvances.2017005926].
Lucena-Araujo, Ar; Pereira-Martins, Da; Koury, Lc; Franca-Neto, Pl; Coelho-Silva, Jl; de Deus Wagatsuma, Vm; Melo, Ram; Bittencourt, R; Pagnano, K; Pasquini, R; Chiattone, Cs; Fagundes, Em; Chauffaille, Mdl; Schrier, Sl; Tallman, Ms; Ribeiro, Rc; Grimwade, D; Ganser, A; Löwenberg, B; Lo-Coco, F; Sanz, Ma; Berliner, N; Rego, Em
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/194648
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