Risk factors may play a fundamental role in the evolution from a stable to a vulnerable plaque. In particular, the hyperfibrinogenemia, independently from other risk factors, influences the natural history of cerebrovascular disease modifying the histologic composition of atherosclerotic plaques and precipitates carotid thrombosis resulting from rupture of the plaque. Determination of plasma fibrinogen may help to identify a subset of patients at high risk for a rapid progression of carotid atherosclerosis and related clinical events. We suggest that these patients may benefit of an earlier surgical intervention even if the degree of carotid stenosis is not severe.

Spagnoli, L., Mauriello, A., Fratoni, S., Anemona, L., Bonanno, E. (2002). [Risk factors of transient cerebral ischemic episodes: hyperfibrinogenemia and carotid histopathology]. RECENTI PROGRESSI IN MEDICINA, 93(5), 318-321.

[Risk factors of transient cerebral ischemic episodes: hyperfibrinogenemia and carotid histopathology]

Spagnoli L
Membro del Collaboration Group
;
Mauriello A
Writing – Review & Editing
;
Anemona L
Membro del Collaboration Group
;
Bonanno E.
Membro del Collaboration Group
2002-05-01

Abstract

Risk factors may play a fundamental role in the evolution from a stable to a vulnerable plaque. In particular, the hyperfibrinogenemia, independently from other risk factors, influences the natural history of cerebrovascular disease modifying the histologic composition of atherosclerotic plaques and precipitates carotid thrombosis resulting from rupture of the plaque. Determination of plasma fibrinogen may help to identify a subset of patients at high risk for a rapid progression of carotid atherosclerosis and related clinical events. We suggest that these patients may benefit of an earlier surgical intervention even if the degree of carotid stenosis is not severe.
mag-2002
Pubblicato
Rilevanza nazionale
Articolo
Esperti anonimi
Settore MED/08 - ANATOMIA PATOLOGICA
Italian
Ischemic Attack, Transient; Hematologic Diseases; Risk Factors; Humans; Fibrinogen; Arteriosclerosis; Carotid Artery Diseases
Spagnoli, L., Mauriello, A., Fratoni, S., Anemona, L., Bonanno, E. (2002). [Risk factors of transient cerebral ischemic episodes: hyperfibrinogenemia and carotid histopathology]. RECENTI PROGRESSI IN MEDICINA, 93(5), 318-321.
Spagnoli, L; Mauriello, A; Fratoni, S; Anemona, L; Bonanno, E
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/194367
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