The Autism Spectrum Quotient (AQ) has been used to define the 'broader' (BAP), 'medium' (MAP) and 'narrow' autism phenotypes (NAP). We used a new Italian version of the AQ to test if difference on AQ scores and the distribution of BAP, MAP and NAP in autism parents (n = 245) versus control parents (n = 300) were replicated in a Sicilian sample. Parents of children with autism spectrum conditions scored higher than the control parents on total AQ, social skills and communication subscales, and exhibited higher rates of BAP, MAP and NAP. We conclude that the Italian AQ is a cross-culturally reliable measure of these different phenotypes, and can be used to identify a phenotypic gradient of severity of autistic traits in families. To understand the molecular basis of these phenotypes will require its use in genetic association studies.

Ruta, L., Mazzone, D., Mazzone, L., Wheelwright, S., & Baron-Cohen, S. (2012). The autism-spectrum quotient - Italian version: A cross- cultural confirmation of the broader autism phenotype. JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 42(4), 625-633 [10.1007/s10803-011-1290-1].

The autism-spectrum quotient - Italian version: A cross- cultural confirmation of the broader autism phenotype

Mazzone L.
;
2012

Abstract

The Autism Spectrum Quotient (AQ) has been used to define the 'broader' (BAP), 'medium' (MAP) and 'narrow' autism phenotypes (NAP). We used a new Italian version of the AQ to test if difference on AQ scores and the distribution of BAP, MAP and NAP in autism parents (n = 245) versus control parents (n = 300) were replicated in a Sicilian sample. Parents of children with autism spectrum conditions scored higher than the control parents on total AQ, social skills and communication subscales, and exhibited higher rates of BAP, MAP and NAP. We conclude that the Italian AQ is a cross-culturally reliable measure of these different phenotypes, and can be used to identify a phenotypic gradient of severity of autistic traits in families. To understand the molecular basis of these phenotypes will require its use in genetic association studies.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/39 - Neuropsichiatria Infantile
English
Con Impact Factor ISI
Adult; Child; Child Development Disorders, Pervasive; Culture; Humans; Italy; Middle Aged; Phenotype; Psychometrics; Surveys and Questionnaires; Parents
Ruta, L., Mazzone, D., Mazzone, L., Wheelwright, S., & Baron-Cohen, S. (2012). The autism-spectrum quotient - Italian version: A cross- cultural confirmation of the broader autism phenotype. JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 42(4), 625-633 [10.1007/s10803-011-1290-1].
Ruta, L; Mazzone, D; Mazzone, L; Wheelwright, S; Baron-Cohen, S
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/194091
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