Despite its beneficial role on insulin resistance and atherosclerosis, adiponectin has been frequently reported as an independent positive predictor of cardiovascular mortality. Very few information is available regarding adiponectin isoforms and mortality, in particular in advanced aging. Baseline serum levels of Total Adiponectin and its circulating isoforms (HMW-, MMW-, LMW-Adiponectin) were measured in 97 old patients (mean age: 79 years). Patients were followed up for all-cause mortality (study end-point) for an average of 76.4 ± 37.3 months. A positive association was observed for LMW-Ad and all-cause mortality (HR: 1.13, 95% CI: 1.05-1,22, p: 0.002). After multivariate adjustment for age, sex and a previous history of myocardial infarction, higher levels of LMW-Ad were significantly associated with all-cause mortality (HR: 1.11, 95% CI: 1.02-1.21; p: 0.017). Interestingly neither total adiponectin neither the other two circulating isoforms (MMW- and HMW-Ad) showed any significant association with the study end-point. Our data suggest that the association between high serum adiponectin levels and increased mortality rate in elderly is contingent to an unbalanced circulating levels of adiponectin isoforms. The present results support the hypothesis that high levels of Low Molecular Weight adiponectin are a biomarker for mortality risk in very old patients.

Rizza, S., Cardellini, M., Farcomeni, A., Morabito, P., Romanello, D., DI COLA, G., et al. (2018). Low Molecular Weight Adiponectin Increases the Mortality Risk in Very Old Patients. AGING AND DISEASE, 9(5), 946-951.

Low Molecular Weight Adiponectin Increases the Mortality Risk in Very Old Patients

Stefano Rizza
Writing – Original Draft Preparation
;
Marina Cardellini
Membro del Collaboration Group
;
Alessio Farcomeni
Formal Analysis
;
Giovanni Di Cola
Membro del Collaboration Group
;
Maria Paola Canale
Membro del Collaboration Group
;
Massimo Federici
Supervision
2018

Abstract

Despite its beneficial role on insulin resistance and atherosclerosis, adiponectin has been frequently reported as an independent positive predictor of cardiovascular mortality. Very few information is available regarding adiponectin isoforms and mortality, in particular in advanced aging. Baseline serum levels of Total Adiponectin and its circulating isoforms (HMW-, MMW-, LMW-Adiponectin) were measured in 97 old patients (mean age: 79 years). Patients were followed up for all-cause mortality (study end-point) for an average of 76.4 ± 37.3 months. A positive association was observed for LMW-Ad and all-cause mortality (HR: 1.13, 95% CI: 1.05-1,22, p: 0.002). After multivariate adjustment for age, sex and a previous history of myocardial infarction, higher levels of LMW-Ad were significantly associated with all-cause mortality (HR: 1.11, 95% CI: 1.02-1.21; p: 0.017). Interestingly neither total adiponectin neither the other two circulating isoforms (MMW- and HMW-Ad) showed any significant association with the study end-point. Our data suggest that the association between high serum adiponectin levels and increased mortality rate in elderly is contingent to an unbalanced circulating levels of adiponectin isoforms. The present results support the hypothesis that high levels of Low Molecular Weight adiponectin are a biomarker for mortality risk in very old patients.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/09 - Medicina Interna
Settore MED/49 - Scienze Tecniche Dietetiche Applicate
English
adiponectin, isoforms, mortality, aging
Rizza, S., Cardellini, M., Farcomeni, A., Morabito, P., Romanello, D., DI COLA, G., et al. (2018). Low Molecular Weight Adiponectin Increases the Mortality Risk in Very Old Patients. AGING AND DISEASE, 9(5), 946-951.
Rizza, S; Cardellini, M; Farcomeni, A; Morabito, P; Romanello, D; DI COLA, G; Canale, Mp; Federici, M
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/193909
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