Nevirapine (NVP) is used in developing countries as first-line treatment of HIV infection. Unfortunately, its use is associated with common serious adverse drug reactions, such as liver toxicity and the most severe and rare Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). GSTT1 and GSTM1 genes code for enzymes involved in the metabolism of a wide range of drugs. We hypothesized that this gene variability could be implicated in NVP adverse reactions.

Ciccacci, C., Latini, A., Politi, C., Mancinelli, S., Marazzi, M.c., Novelli, G., et al. (2017). Impact of glutathione transferases genes polymorphisms in nevirapine adverse reactions: a possible role for GSTM1 in SJS/TEN susceptibility. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 73(10), 1253-1259 [10.1007/s00228-017-2295-2].

Impact of glutathione transferases genes polymorphisms in nevirapine adverse reactions: a possible role for GSTM1 in SJS/TEN susceptibility

Ciccacci C.;Mancinelli S.;Novelli G.;Palombi L.;Borgiani P.
2017

Abstract

Nevirapine (NVP) is used in developing countries as first-line treatment of HIV infection. Unfortunately, its use is associated with common serious adverse drug reactions, such as liver toxicity and the most severe and rare Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). GSTT1 and GSTM1 genes code for enzymes involved in the metabolism of a wide range of drugs. We hypothesized that this gene variability could be implicated in NVP adverse reactions.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/03 - Genetica Medica
English
Con Impact Factor ISI
Glutathione S-transferases; NVP adverse reactions; Polymorphisms; Stevens-Johnson syndrome; Toxic epidermal necrolysis
Ciccacci, C., Latini, A., Politi, C., Mancinelli, S., Marazzi, M.c., Novelli, G., et al. (2017). Impact of glutathione transferases genes polymorphisms in nevirapine adverse reactions: a possible role for GSTM1 in SJS/TEN susceptibility. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 73(10), 1253-1259 [10.1007/s00228-017-2295-2].
Ciccacci, C; Latini, A; Politi, C; Mancinelli, S; Marazzi, Mc; Novelli, G; Palombi, L; Borgiani, P
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/193660
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