The "tissue" transglutaminase is a multifunctional enzyme that in its cross-linking configuration catalyzes Ca2+ -dependent reactions resulting in post-translational modification of proteins by establishing epsilon(gamma-glutamyl) lysine cross-links and/or covalent incorporation of biogenic amines (di- and poly-amines and histamine) into proteins. Several laboratories have shown that in Vertebrates, "tissue" transglutaminase (tTG) gene expression specifically characterizes cells undergoing apoptosis or programmed cell death (PCD). The Ca2+ -dependent activation of this enzyme leads to the formation of detergent-insoluble cross-linked protein polymers in cells undergoing PCD. This insoluble protein scaffold could stabilize the integrity of the dying cells before their clearance by phagocytosis, preventing the non-specific release of harmful intracellular components (e.g. lysosomal enzymes, nucleic acids, etc.) and consequently inflammatory responses and scar formation in bystander tissues. In this review we attempt to present an overview of the current knowledge on tTG expression and regulation in animal reproduction and development. The data available so far further strengthen the relationship existing between tTG expression and the induction of PCD.

Piacentini, M., Rodolfo, C., Farrace, M.g., Autuori, F. (2000). Tissue transglutaminase in animal development. THE INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 44(6), 655-662.

Tissue transglutaminase in animal development

PIACENTINI, MAURO;RODOLFO, CARLO;FARRACE, MARIA GRAZIA;AUTUORI, FRANCESCO
2000-01-01

Abstract

The "tissue" transglutaminase is a multifunctional enzyme that in its cross-linking configuration catalyzes Ca2+ -dependent reactions resulting in post-translational modification of proteins by establishing epsilon(gamma-glutamyl) lysine cross-links and/or covalent incorporation of biogenic amines (di- and poly-amines and histamine) into proteins. Several laboratories have shown that in Vertebrates, "tissue" transglutaminase (tTG) gene expression specifically characterizes cells undergoing apoptosis or programmed cell death (PCD). The Ca2+ -dependent activation of this enzyme leads to the formation of detergent-insoluble cross-linked protein polymers in cells undergoing PCD. This insoluble protein scaffold could stabilize the integrity of the dying cells before their clearance by phagocytosis, preventing the non-specific release of harmful intracellular components (e.g. lysosomal enzymes, nucleic acids, etc.) and consequently inflammatory responses and scar formation in bystander tissues. In this review we attempt to present an overview of the current knowledge on tTG expression and regulation in animal reproduction and development. The data available so far further strengthen the relationship existing between tTG expression and the induction of PCD.
2000
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/06 - ANATOMIA COMPARATA E CITOLOGIA
English
Con Impact Factor ISI
Transglutaminases; Apoptosis; Embryonic Development; Mesoderm; Lung; Immunohistochemistry; Embryo, Mammalian; Embryo, Nonmammalian; Animals; Skin; Humans
http://www.ijdb.ehu.es/web/pdfdownload.php?doi=11061429
Piacentini, M., Rodolfo, C., Farrace, M.g., Autuori, F. (2000). Tissue transglutaminase in animal development. THE INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 44(6), 655-662.
Piacentini, M; Rodolfo, C; Farrace, Mg; Autuori, F
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/19314
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