Programmed cell death (PCD) by apoptosis has been widely characterized as a process in which the expression and protein activation of a gene must be regulated in a very precise way in order to achieve the elimination of the dying cell without disturbing the neighborhoods. One of the first genes observed to be induced during the onset of PCD is the one coding for type 2 transglutaminase (TG2). Since the late 1990s, the unveiling of different new properties and enzymatic activities suggested the involvement of TG2 in a variety of cellular processes other than PCD and rendered the study of this protein more and more complicated.

Rodolfo, C., Falasca, L., Di Giacomo, G., Mastroberardino, P., Piacentini, M. (2008). More than two sides of a coin? How to detect the multiple activities of type 2 transglutaminase, 442, 201-212 [10.1016/S0076-6879(08)01410-9].

More than two sides of a coin? How to detect the multiple activities of type 2 transglutaminase

RODOLFO, CARLO;PIACENTINI, MAURO
2008-01-01

Abstract

Programmed cell death (PCD) by apoptosis has been widely characterized as a process in which the expression and protein activation of a gene must be regulated in a very precise way in order to achieve the elimination of the dying cell without disturbing the neighborhoods. One of the first genes observed to be induced during the onset of PCD is the one coding for type 2 transglutaminase (TG2). Since the late 1990s, the unveiling of different new properties and enzymatic activities suggested the involvement of TG2 in a variety of cellular processes other than PCD and rendered the study of this protein more and more complicated.
2008
Pubblicato
Rilevanza internazionale
Capitolo o saggio
Nessuno
Settore BIO/06 - ANATOMIA COMPARATA E CITOLOGIA
English
Con Impact Factor ISI
Transglutaminases; Phagocytosis; Fluorescent Antibody Technique; Apoptosis; Mice; Immunohistochemistry; Mice, Knockout; Animals; Humans; Biotinylation
Rodolfo, C., Falasca, L., Di Giacomo, G., Mastroberardino, P., Piacentini, M. (2008). More than two sides of a coin? How to detect the multiple activities of type 2 transglutaminase, 442, 201-212 [10.1016/S0076-6879(08)01410-9].
Rodolfo, C; Falasca, L; Di Giacomo, G; Mastroberardino, P; Piacentini, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/19311
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