Plasmodium falciparum sporozoites injected by mosquitoes into the blood rapidly enter liver hepatocytes and undergo pre-erythrocytic developmental schizogony forming tens of thousands of merozoites per hepatocyte. Shortly after hepatocyte invasion, the parasite starts to produce Liver Stage Antigen-1 (LSA-1), which accumulates within the parasitophorous vacuole surrounding the mass of developing merozoites. The LSA-1 protein has been described as a flocculent mass, but its role in parasite development has not been determined.

Nicoll, W., Sacci, J., Rodolfo, C., Di Giacomo, G., Piacentini, M., Holland, Z., et al. (2011). Plasmodium falciparum liver stage antigen-1 is cross-linked by tissue transglutaminase. MALARIA JOURNAL, 10, 14 [10.1186/1475-2875-10-14].

Plasmodium falciparum liver stage antigen-1 is cross-linked by tissue transglutaminase

RODOLFO, CARLO;PIACENTINI, MAURO;
2011-01-01

Abstract

Plasmodium falciparum sporozoites injected by mosquitoes into the blood rapidly enter liver hepatocytes and undergo pre-erythrocytic developmental schizogony forming tens of thousands of merozoites per hepatocyte. Shortly after hepatocyte invasion, the parasite starts to produce Liver Stage Antigen-1 (LSA-1), which accumulates within the parasitophorous vacuole surrounding the mass of developing merozoites. The LSA-1 protein has been described as a flocculent mass, but its role in parasite development has not been determined.
2011
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/06 - ANATOMIA COMPARATA E CITOLOGIA
English
Con Impact Factor ISI
Transglutaminases; Malaria, Falciparum; Liver; Microscopy, Fluorescence; Antigens, Protozoan; Mice; Plasmodium falciparum; Host-Parasite Interactions; Mice, SCID; Animals; Humans
Nicoll, W., Sacci, J., Rodolfo, C., Di Giacomo, G., Piacentini, M., Holland, Z., et al. (2011). Plasmodium falciparum liver stage antigen-1 is cross-linked by tissue transglutaminase. MALARIA JOURNAL, 10, 14 [10.1186/1475-2875-10-14].
Nicoll, W; Sacci, J; Rodolfo, C; Di Giacomo, G; Piacentini, M; Holland, Z; Doerig, C; Hollingdale, M; Lanar, D
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/19310
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