Objective(s) Glutathione S-transferases (GSTs) are the main phase II enzymes involved in the cellular detoxification. Through phase I and phase II detoxification reactions, the cell is able to detoxify endogenous and exogenous toxic compounds. In this study, we focused our attention on the GSTA1∗-69C/T gene polymorphism (rs3957357) in order to explore its involvement in the genetic predisposition to gestational hypertension (GH). Study design The case-control population consists of 195 subjects. The genotyping of the GSTA1∗-69C/T was performed by using an RFLP-PCR technique. We calculated odds ratios (ORs), adjusted for the confounding variables, to estimate the association between GSTA1 and GH. Results Significant allelic differences in GSTA1∗-69C/T are present between GH women and pregnant women without cardiovascular complications (p < 0.05). Specifically, we observed that the dominant genetic model best explains the observed genetic association, according to the Akaike information criterion and the Bayesian information criterion. Conclusion(s) Our study highlighted a significant association between the GSTA1 gene and the risk of GH in Italian patients. In particular, the -69C/T variant was significantly associated with disease risk. Since previous studies indicated that this GSTA1 polymorphism is associated with different pregnancy-related conditions, our finding supports the notion that GSTA1 may play a key role during pregnancy.

Iorio, A., Spinelli, M., Polimanti, R., Lorenzi, F., Valensise, H., Manfellotto, D., et al. (2015). GSTA1 gene variation associated with gestational hypertension and its involvement in pregnancy-related pathogenic conditions. EUROPEAN JOURNAL OF OBSTETRICS, GYNECOLOGY, AND REPRODUCTIVE BIOLOGY, 194, 34-37 [10.1016/j.ejogrb.2015.08.006].

GSTA1 gene variation associated with gestational hypertension and its involvement in pregnancy-related pathogenic conditions

Iorio, Andrea;Polimanti, Renato;Valensise, Herbert;Fuciarelli, Maria
2015-01-01

Abstract

Objective(s) Glutathione S-transferases (GSTs) are the main phase II enzymes involved in the cellular detoxification. Through phase I and phase II detoxification reactions, the cell is able to detoxify endogenous and exogenous toxic compounds. In this study, we focused our attention on the GSTA1∗-69C/T gene polymorphism (rs3957357) in order to explore its involvement in the genetic predisposition to gestational hypertension (GH). Study design The case-control population consists of 195 subjects. The genotyping of the GSTA1∗-69C/T was performed by using an RFLP-PCR technique. We calculated odds ratios (ORs), adjusted for the confounding variables, to estimate the association between GSTA1 and GH. Results Significant allelic differences in GSTA1∗-69C/T are present between GH women and pregnant women without cardiovascular complications (p < 0.05). Specifically, we observed that the dominant genetic model best explains the observed genetic association, according to the Akaike information criterion and the Bayesian information criterion. Conclusion(s) Our study highlighted a significant association between the GSTA1 gene and the risk of GH in Italian patients. In particular, the -69C/T variant was significantly associated with disease risk. Since previous studies indicated that this GSTA1 polymorphism is associated with different pregnancy-related conditions, our finding supports the notion that GSTA1 may play a key role during pregnancy.
2015
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/08 - ANTROPOLOGIA
English
Con Impact Factor ISI
Detoxification; Gestation; Glutathione S-transferases; Hypertension; Single nucleotide polymorphism; Adult; Case-Control Studies; Female; Glutathione Transferase; Humans; Hypertension, Pregnancy-Induced; Male; Pregnancy; Polymorphism, Single Nucleotide; Reproductive Medicine; Obstetrics and Gynecology
www.elsevier.com/locate/ejogrb
Iorio, A., Spinelli, M., Polimanti, R., Lorenzi, F., Valensise, H., Manfellotto, D., et al. (2015). GSTA1 gene variation associated with gestational hypertension and its involvement in pregnancy-related pathogenic conditions. EUROPEAN JOURNAL OF OBSTETRICS, GYNECOLOGY, AND REPRODUCTIVE BIOLOGY, 194, 34-37 [10.1016/j.ejogrb.2015.08.006].
Iorio, A; Spinelli, M; Polimanti, R; Lorenzi, F; Valensise, H; Manfellotto, D; Fuciarelli, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/192997
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