We previously showed that proprioceptive sensory input from the hindlimbs to the anterior cerebellar cortex of the cat may not be simply organized with respect to a body map, but it may also be distributed to multiple discrete functional areas extending beyond classical body map boundaries. With passive hindlimb stepping movements, cerebellar activity was shown to relate to whole limb kinematics as does the activity of dorsal spinocerebellar tract (DSCT) neurons. For DSCT activity, whole limb kinematics provides a solid functional framework within which information about limb forces, such as those generated during active stepping, may also be embedded. In this study, we investigated this idea for the spinocerebellar cortex activity by examining the activity of cerebellar cortical neurons during both passive bipedal hindlimb stepping and active stepping on a treadmill. Our results showed a functional compartmentalization of cerebellar responses to hindlimb stepping movements depending on the two types of stepping and strong relationships between neural activities and limb axis kinematics during both. In fact, responses to passive and active stepping were generally different, but in both cases their waveforms were related strongly to the limb axis kinematics. That is, the different stepping conditions modified the kinematics representation without producing different components in the response waveforms. In sum, cerebellar activity was consistent with a global kinematics framework serving as a basis upon which detailed information about limb mechanics and/or about individual limb segments might be imposed.

Valle, M.s., Bosco, G., Poppele, R.e. (2017). Cerebellar compartments for the processing of kinematic and kinetic information related to hindlimb stepping. EXPERIMENTAL BRAIN RESEARCH, 235(11), 3437-3448 [10.1007/s00221-017-5067-4].

Cerebellar compartments for the processing of kinematic and kinetic information related to hindlimb stepping

Bosco G.;
2017

Abstract

We previously showed that proprioceptive sensory input from the hindlimbs to the anterior cerebellar cortex of the cat may not be simply organized with respect to a body map, but it may also be distributed to multiple discrete functional areas extending beyond classical body map boundaries. With passive hindlimb stepping movements, cerebellar activity was shown to relate to whole limb kinematics as does the activity of dorsal spinocerebellar tract (DSCT) neurons. For DSCT activity, whole limb kinematics provides a solid functional framework within which information about limb forces, such as those generated during active stepping, may also be embedded. In this study, we investigated this idea for the spinocerebellar cortex activity by examining the activity of cerebellar cortical neurons during both passive bipedal hindlimb stepping and active stepping on a treadmill. Our results showed a functional compartmentalization of cerebellar responses to hindlimb stepping movements depending on the two types of stepping and strong relationships between neural activities and limb axis kinematics during both. In fact, responses to passive and active stepping were generally different, but in both cases their waveforms were related strongly to the limb axis kinematics. That is, the different stepping conditions modified the kinematics representation without producing different components in the response waveforms. In sum, cerebellar activity was consistent with a global kinematics framework serving as a basis upon which detailed information about limb mechanics and/or about individual limb segments might be imposed.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/09
English
Con Impact Factor ISI
Kinematics; Locomotion; Sensorimotor integration; Sensory mapping
Valle, M.s., Bosco, G., Poppele, R.e. (2017). Cerebellar compartments for the processing of kinematic and kinetic information related to hindlimb stepping. EXPERIMENTAL BRAIN RESEARCH, 235(11), 3437-3448 [10.1007/s00221-017-5067-4].
Valle, Ms; Bosco, G; Poppele, Re
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/192589
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