Polycystic ovary syndrome (PCOS) is the most common endocrine abnormality in women of reproductive age. Although its clinical consequences have been known for a long time to extend beyond the reproductive system, with type-2 diabetes and obesity being the most common, the involvement of the ocular surface in PCOS has been described only more recently. The ocular surface is a morphofunctional unit comprising eyelid margin, tear film, cornea, and conjunctiva. Increasing evidence indicates that these structures are under a sex hormone control and relevant diseases such as ocular allergy and dry eye are often caused by alterations in circulating or local steroid hormones levels. Novel treatments targeting sex hormone receptors on ocular surface epithelial cells are also being developed. In this review we aim to describe the current knowledge on the effects of sex hormones at the ocular surface, with a special focus on the effects of androgen imbalance in PCOS.

Mantelli, F., Moretti, C., Macchi, I., Massaro-Giordano, G., Cozzupoli, G.m., Lambiase, A., et al. (2016). Effects of Sex Hormones on Ocular Surface Epithelia: Lessons Learned From Polycystic Ovary Syndrome. JOURNAL OF CELLULAR PHYSIOLOGY, 231(5), 971-975 [10.1002/jcp.25221].

Effects of Sex Hormones on Ocular Surface Epithelia: Lessons Learned From Polycystic Ovary Syndrome

Moretti C.;
2016

Abstract

Polycystic ovary syndrome (PCOS) is the most common endocrine abnormality in women of reproductive age. Although its clinical consequences have been known for a long time to extend beyond the reproductive system, with type-2 diabetes and obesity being the most common, the involvement of the ocular surface in PCOS has been described only more recently. The ocular surface is a morphofunctional unit comprising eyelid margin, tear film, cornea, and conjunctiva. Increasing evidence indicates that these structures are under a sex hormone control and relevant diseases such as ocular allergy and dry eye are often caused by alterations in circulating or local steroid hormones levels. Novel treatments targeting sex hormone receptors on ocular surface epithelial cells are also being developed. In this review we aim to describe the current knowledge on the effects of sex hormones at the ocular surface, with a special focus on the effects of androgen imbalance in PCOS.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/13 - Endocrinologia
English
Con Impact Factor ISI
Epithelium; Eye; Female; Gonadal Steroid Hormones; Humans; Polycystic Ovary Syndrome; Receptors, Cell Surface; Tears
Mantelli, F., Moretti, C., Macchi, I., Massaro-Giordano, G., Cozzupoli, G.m., Lambiase, A., et al. (2016). Effects of Sex Hormones on Ocular Surface Epithelia: Lessons Learned From Polycystic Ovary Syndrome. JOURNAL OF CELLULAR PHYSIOLOGY, 231(5), 971-975 [10.1002/jcp.25221].
Mantelli, F; Moretti, C; Macchi, I; Massaro-Giordano, G; Cozzupoli, Gm; Lambiase, A; Bonini, S
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/192397
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