This review was designed to revaluate the androgen role on the mechanisms of hypertension and cardiovascular risks in both men and women. Sex steroids are involved in the regulation of blood pressure, but pathophysiological mechanism is not well understood. Androgens have an important effect on metabolism, adipose and endothelial cell function, and cardiovascular risk in both men and women. A focal point in this contest is represented by the possible gender-specific regulation of different tissues and in particular of the adipose cell. Available data confirm that androgen deficiency is linked to increased prevalence of hypertension and cardiovascular diseases. Adipocyte dysfunction seems to be the main involved mechanism. Androgen replacement reduces inflammation state in man, protecting by metabolic syndrome progression. In women, androgen excess has been considered as promoting factor of cardiovascular risk. However, recent data suggest that excessive androgen production has little effect per se in inducing hypertension in young women of reproductive age. Also in postmenopausal women, data on relative androgen excess and hypertension are missing, while adrenal androgen deficiency has been associated to increased mortality.

Moretti, C., Lanzolla, G., Moretti, M., Gnessi, L., & Carmina, E. (2017). Androgens and Hypertension in Men and Women: a Unifying View. CURRENT HYPERTENSION REPORTS, 19(5), 44 [10.1007/s11906-017-0740-3].

Androgens and Hypertension in Men and Women: a Unifying View

Moretti C.;
2017

Abstract

This review was designed to revaluate the androgen role on the mechanisms of hypertension and cardiovascular risks in both men and women. Sex steroids are involved in the regulation of blood pressure, but pathophysiological mechanism is not well understood. Androgens have an important effect on metabolism, adipose and endothelial cell function, and cardiovascular risk in both men and women. A focal point in this contest is represented by the possible gender-specific regulation of different tissues and in particular of the adipose cell. Available data confirm that androgen deficiency is linked to increased prevalence of hypertension and cardiovascular diseases. Adipocyte dysfunction seems to be the main involved mechanism. Androgen replacement reduces inflammation state in man, protecting by metabolic syndrome progression. In women, androgen excess has been considered as promoting factor of cardiovascular risk. However, recent data suggest that excessive androgen production has little effect per se in inducing hypertension in young women of reproductive age. Also in postmenopausal women, data on relative androgen excess and hypertension are missing, while adrenal androgen deficiency has been associated to increased mortality.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/13 - Endocrinologia
English
Con Impact Factor ISI
Adipokines; Androgen receptor; Androgens; Brown adipose tissue; Cardiovascular disease; Endothelial dysfunction; Hypertension; Metabolic syndrome; NF-kappaB; Obesity; PCOS; Cardiovascular Diseases; Female; Humans; Hypertension; Male; Metabolic Syndrome; Obesity; Polycystic Ovary Syndrome; Postmenopause; Risk Factors; Sex Factors; Androgens; Gonadal Steroid Hormones
Moretti, C., Lanzolla, G., Moretti, M., Gnessi, L., & Carmina, E. (2017). Androgens and Hypertension in Men and Women: a Unifying View. CURRENT HYPERTENSION REPORTS, 19(5), 44 [10.1007/s11906-017-0740-3].
Moretti, C; Lanzolla, G; Moretti, M; Gnessi, L; Carmina, E
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/192393
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