Introduction: Acute bacterial skin and skin structure infections (ABSSIs), defined as a bacterial infection of the skin with a lesion size area of at least 75 cm, are a leading cause of hospital admission and ambulatory care visits worldwide. Dalbavancin is a lipoglycopeptide antibiotic recently approved by the United States Food and Drug Administration (FDA) and by European Medicines Agency (EMA) for ABSSSIs. The authors review and provide updates of efficacy and safety by several studies on dalbavancin. Areas covered: A PubMed search was performed for relevant literature. We especially focused our attention on pharmacokinetics. Expert opinion: Dalbavancin provides an important new therapy for management of ABSSI, maintaining a spectrum of activity similar to vancomycin against gram-positive organisms. Use of dalbavancin, with its 1-week-shot treatment, consist in a reduction of the length of hospital stay or in a reduction of hospital admissions, with important cost savings.

Galluzzo, M., D'Adamio, S., Bianchi, L., Talamonti, M. (2018). Pharmacokinetic drug evaluation of dalbavancin for the treatment of skin infections. EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 14(2), 197-206 [10.1080/17425255.2018.1420162].

Pharmacokinetic drug evaluation of dalbavancin for the treatment of skin infections

Galluzzo, M;Bianchi, L;Talamonti, M.
2018-01-01

Abstract

Introduction: Acute bacterial skin and skin structure infections (ABSSIs), defined as a bacterial infection of the skin with a lesion size area of at least 75 cm, are a leading cause of hospital admission and ambulatory care visits worldwide. Dalbavancin is a lipoglycopeptide antibiotic recently approved by the United States Food and Drug Administration (FDA) and by European Medicines Agency (EMA) for ABSSSIs. The authors review and provide updates of efficacy and safety by several studies on dalbavancin. Areas covered: A PubMed search was performed for relevant literature. We especially focused our attention on pharmacokinetics. Expert opinion: Dalbavancin provides an important new therapy for management of ABSSI, maintaining a spectrum of activity similar to vancomycin against gram-positive organisms. Use of dalbavancin, with its 1-week-shot treatment, consist in a reduction of the length of hospital stay or in a reduction of hospital admissions, with important cost savings.
2018
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/35 - MALATTIE CUTANEE E VENEREE
English
Galluzzo, M., D'Adamio, S., Bianchi, L., Talamonti, M. (2018). Pharmacokinetic drug evaluation of dalbavancin for the treatment of skin infections. EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 14(2), 197-206 [10.1080/17425255.2018.1420162].
Galluzzo, M; D'Adamio, S; Bianchi, L; Talamonti, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/192235
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