Central neuropathic pain (CNP) is common and disabling among patients with multiple sclerosis (MS). The pathological mechanisms underlying CNP in MS are not well understood. We explored whether NGF is implicated in the pathogenesis of CNP in MS. We measured NGF concentration in the CSF of 73 patients affected by MS, 15 with and 58 without CNP and 14 controls. We found increased levels of NGF in the CSF of patients with CNP compared to patients without and to controls. This finding supports the hypothesis that NGF plays a role in MS related CNP.

Monteleone, F., Nicoletti, C.g., Stampanoni Bassi, M., Iezzi, E., Buttari, F., Furlan, R., et al. (2017). Nerve growth factor is elevated in the CSF of patients with multiple sclerosis and central neuropathic pain. JOURNAL OF NEUROIMMUNOLOGY [10.1016/j.jneuroim.2017.11.012].

Nerve growth factor is elevated in the CSF of patients with multiple sclerosis and central neuropathic pain

Monteleone F.;Buttari F.;Marfia G. A.;Centonze D.
;
Mori F.
2017

Abstract

Central neuropathic pain (CNP) is common and disabling among patients with multiple sclerosis (MS). The pathological mechanisms underlying CNP in MS are not well understood. We explored whether NGF is implicated in the pathogenesis of CNP in MS. We measured NGF concentration in the CSF of 73 patients affected by MS, 15 with and 58 without CNP and 14 controls. We found increased levels of NGF in the CSF of patients with CNP compared to patients without and to controls. This finding supports the hypothesis that NGF plays a role in MS related CNP.
Online ahead of print
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/26 - Neurologia
English
Con Impact Factor ISI
Inflammation; MS; Nerve growth factor; Neurotrophins
Monteleone, F., Nicoletti, C.g., Stampanoni Bassi, M., Iezzi, E., Buttari, F., Furlan, R., et al. (2017). Nerve growth factor is elevated in the CSF of patients with multiple sclerosis and central neuropathic pain. JOURNAL OF NEUROIMMUNOLOGY [10.1016/j.jneuroim.2017.11.012].
Monteleone, F; Nicoletti, Cg; Stampanoni Bassi, M; Iezzi, E; Buttari, F; Furlan, R; Finardi, A; Marfia, Ga; Centonze, D; Mori, F
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/191356
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