Mitochondria-shaping proteins control the dynamic equilibrium between fusion and fission of the mitochondrial network. Their balance is strictly required to regulate various processes, including the quality of mitochondria, cell metabolism, cell death, proliferation and cell migration. Alterations in these processes are frequently encountered in cancer, during both its onset and later progression, as evidence emerge connecting alterations in mitochondrial dynamics with cancer development. In recent years, novel therapeutic approaches to fight against different human tumors aim at exploiting the immune system's ability to specifically recognize tumor antigens, thus killing malignant cells in a process named immune-surveillance. Interestingly, data are accumulating on the role that mitochondrial dynamics play also for the correct function of both the innate and the adaptive immune system. By this review, we overview how mitochondrial dynamics can affect various processes during cancer development, acting directly on tumor cells or indirectly on cells responsible for tumor aggression and defence.

Simula, L., Nazio, F., & Campello, S. (2017). The mitochondrial dynamics in cancer and immune-surveillance. SEMINARS IN CANCER BIOLOGY, 47, 29-42 [10.1016/j.semcancer.2017.06.007].

The mitochondrial dynamics in cancer and immune-surveillance

Simula L.;Nazio F.;Campello S.
2017-12

Abstract

Mitochondria-shaping proteins control the dynamic equilibrium between fusion and fission of the mitochondrial network. Their balance is strictly required to regulate various processes, including the quality of mitochondria, cell metabolism, cell death, proliferation and cell migration. Alterations in these processes are frequently encountered in cancer, during both its onset and later progression, as evidence emerge connecting alterations in mitochondrial dynamics with cancer development. In recent years, novel therapeutic approaches to fight against different human tumors aim at exploiting the immune system's ability to specifically recognize tumor antigens, thus killing malignant cells in a process named immune-surveillance. Interestingly, data are accumulating on the role that mitochondrial dynamics play also for the correct function of both the innate and the adaptive immune system. By this review, we overview how mitochondrial dynamics can affect various processes during cancer development, acting directly on tumor cells or indirectly on cells responsible for tumor aggression and defence.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/13
English
Apoptosis; Cancer; Cell migration; Immune-surveillance; Mitochondrial dynamics
Simula, L., Nazio, F., & Campello, S. (2017). The mitochondrial dynamics in cancer and immune-surveillance. SEMINARS IN CANCER BIOLOGY, 47, 29-42 [10.1016/j.semcancer.2017.06.007].
Simula, L; Nazio, F; Campello, S
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/191185
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