The study aim was to evaluate the short-term safety and efficacy of pegaptanib sodium injections (Macugen, Eyetech Pharmaceuticals, Inc., New York, NY) in the compassionate-use therapy of choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD). Intravitreal pegaptanib was used to treat 41 eyes in 40 patients with CNV. Injections were given every 6 weeks, and a minimum of three injections were planned. The mean change in BCVA for all lesions was a loss of 0.03 Snellen lines. Seven eyes (17.1%) gained more than 3 lines, three (7.31%) lost 6 lines or more, and in 75.6% the BCVA stabilized or improved.

Ricci, F., Missiroli, F., Cedrone, C., Grossi, M., Regine, F. (2010). Compassionate use of intravitreal pegaptanib in patients with age-related macular degeneration. SEMINARS IN OPHTHALMOLOGY, 25(1-2), 16-20 [10.3109/08820538.2010.481508].

Compassionate use of intravitreal pegaptanib in patients with age-related macular degeneration

RICCI, FEDERICO;MISSIROLI, FILIPPO;CEDRONE, CLAUDIO;GROSSI, MASSIMO;
2010-01-01

Abstract

The study aim was to evaluate the short-term safety and efficacy of pegaptanib sodium injections (Macugen, Eyetech Pharmaceuticals, Inc., New York, NY) in the compassionate-use therapy of choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD). Intravitreal pegaptanib was used to treat 41 eyes in 40 patients with CNV. Injections were given every 6 weeks, and a minimum of three injections were planned. The mean change in BCVA for all lesions was a loss of 0.03 Snellen lines. Seven eyes (17.1%) gained more than 3 lines, three (7.31%) lost 6 lines or more, and in 75.6% the BCVA stabilized or improved.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/30 - Malattie Apparato Visivo
English
Con Impact Factor ISI
Treatment outcome; aged, 80 and over; choroidal neovascularization; macular degeneration; male; injections; middle aged; female; vitreous body; humans; prospective studies; visual acuity; compassionate use trials; fluorescein angiography; tomography, optical coherence; angiogenesis inhibitors; aged; aptamers, nucleotide
Ricci, F., Missiroli, F., Cedrone, C., Grossi, M., Regine, F. (2010). Compassionate use of intravitreal pegaptanib in patients with age-related macular degeneration. SEMINARS IN OPHTHALMOLOGY, 25(1-2), 16-20 [10.3109/08820538.2010.481508].
Ricci, F; Missiroli, F; Cedrone, C; Grossi, M; Regine, F
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/19040
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