Diabetic sensorimotor polyneuropathy (DSPN) is a common complication in patients with diabetes, >10 % of whom suffer from severe neuropathic pain. DSPN diagnosis remains challenging despite the breath of diagnostic tools; this is partly due to varying proficiency amongst examiners, but also variations in diagnostic criteria employed. Treatment options include pathogenesis-oriented and symptomatic approaches. Symptomatic pharmacotherapy in painful DSPN aims to ease neuropathic pain using analgesics such as the tricyclic antidepressants serotonin-noradrenaline reuptake inhibitors and alpha(2)delta ligands, but evidence points to pathogenesis-oriented treatments using alpha lipoic acid or benfotiamine. Combination therapy has also emerged as an important approach in DSPN treatment. In this review, we aim to update the current diagnostic and therapeutic options for DSPN.

Kempler, P., Czupryniak, L., Garcia Verdugo, R., Gurieve, I., Mankovskys, B., Manske, C., et al. (2017). Perspectives in Diabetic Neuropathy: Update on Diagnostic Criteria and Treatment Options. DIABETES, STOFFWECHSEL UND HERZ, 26(5), 279-285.

Perspectives in Diabetic Neuropathy: Update on Diagnostic Criteria and Treatment Options

SPALLONE, VINCENZA;
2017-09

Abstract

Diabetic sensorimotor polyneuropathy (DSPN) is a common complication in patients with diabetes, >10 % of whom suffer from severe neuropathic pain. DSPN diagnosis remains challenging despite the breath of diagnostic tools; this is partly due to varying proficiency amongst examiners, but also variations in diagnostic criteria employed. Treatment options include pathogenesis-oriented and symptomatic approaches. Symptomatic pharmacotherapy in painful DSPN aims to ease neuropathic pain using analgesics such as the tricyclic antidepressants serotonin-noradrenaline reuptake inhibitors and alpha(2)delta ligands, but evidence points to pathogenesis-oriented treatments using alpha lipoic acid or benfotiamine. Combination therapy has also emerged as an important approach in DSPN treatment. In this review, we aim to update the current diagnostic and therapeutic options for DSPN.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/13 - Endocrinologia
English
Con Impact Factor ISI
diabetic neuropathy; diagnosis; combination therapy; symptomatic treatment; pathogenesis-oriented treatment
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Kempler, P., Czupryniak, L., Garcia Verdugo, R., Gurieve, I., Mankovskys, B., Manske, C., et al. (2017). Perspectives in Diabetic Neuropathy: Update on Diagnostic Criteria and Treatment Options. DIABETES, STOFFWECHSEL UND HERZ, 26(5), 279-285.
Kempler, P; Czupryniak, L; Garcia Verdugo, R; Gurieve, I; Mankovskys, B; Manske, C; Schnell, O; Spallone, V; Stirban, A; Tesfaye, S; Veresiu, I; Ziegler, D
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/189896
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