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EnglishThe expression of L-selectin (CD62L) in HIV-1 infection has not been extensively investigated. Here, we measured CD62L expression on T-cell subsets of HIV-1-infected individuals naive for antiretroviral therapy (ART-naive) or receiving therapy (ART), and seronegative control subjects (HIV-neg). We found reduced frequencies of CD62L cells among CD4 and CD8 T cells from ART-naive as compared with ART and HIV-neg groups, particularly within naive and central memory subsets. CD62L expression on T cells inversely correlated with viral load and rapidly increased after ART initiation. Plasma sCD62L levels did not correlate with CD62L expression, being higher in all HIV-1-infected individuals as compared with HIV-neg subjects. Finally, CD62L downregulation was found associated with the expression of the CD38 activation marker in CD8 T cells, but not in CD4 T cells. We suggest that CD62L downregulation due to unconstrained HIV-1 replication may have important consequences for T-cell circulation and function and for disease progression.
Vassena, L., Giuliani, E., Buonomini, A.r., Malagnino, V., Andreoni, M., & Doria, M. (2016). Brief report: L-selectin (CD62L) is downregulated on CD4+ and CD8+ T lymphocytes of HIV-1-infected individuals naive for ART. JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 72(5), 492-497 [10.1097/QAI.0000000000000999].
| Tipologia: | Articolo su rivista | |
| Citazione: | Vassena, L., Giuliani, E., Buonomini, A.r., Malagnino, V., Andreoni, M., & Doria, M. (2016). Brief report: L-selectin (CD62L) is downregulated on CD4+ and CD8+ T lymphocytes of HIV-1-infected individuals naive for ART. JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 72(5), 492-497 [10.1097/QAI.0000000000000999]. | |
| Lingua: | English | |
| Settore Scientifico Disciplinare: | Settore MED/17 - Malattie Infettive | |
| Revisione (peer review): | Esperti anonimi | |
| Tipo: | Articolo | |
| Rilevanza: | Rilevanza internazionale | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1097/QAI.0000000000000999 | |
| Stato di pubblicazione: | Pubblicato | |
| Data di pubblicazione: | 15-ago-2016 | |
| Titolo: | Brief report: L-selectin (CD62L) is downregulated on CD4+ and CD8+ T lymphocytes of HIV-1-infected individuals naive for ART | |
| Autori: | ||
| Autori: | Vassena, L; Giuliani, E; Buonomini, Ar; Malagnino, V; Andreoni, M; Doria, M | |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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