The expression of L-selectin (CD62L) in HIV-1 infection has not been extensively investigated. Here, we measured CD62L expression on T-cell subsets of HIV-1-infected individuals naive for antiretroviral therapy (ART-naive) or receiving therapy (ART), and seronegative control subjects (HIV-neg). We found reduced frequencies of CD62L cells among CD4 and CD8 T cells from ART-naive as compared with ART and HIV-neg groups, particularly within naive and central memory subsets. CD62L expression on T cells inversely correlated with viral load and rapidly increased after ART initiation. Plasma sCD62L levels did not correlate with CD62L expression, being higher in all HIV-1-infected individuals as compared with HIV-neg subjects. Finally, CD62L downregulation was found associated with the expression of the CD38 activation marker in CD8 T cells, but not in CD4 T cells. We suggest that CD62L downregulation due to unconstrained HIV-1 replication may have important consequences for T-cell circulation and function and for disease progression.

Vassena, L., Giuliani, E., Buonomini, A.r., Malagnino, V., Andreoni, M., & Doria, M. (2016). Brief report: L-selectin (CD62L) is downregulated on CD4+ and CD8+ T lymphocytes of HIV-1-infected individuals naive for ART. JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 72(5), 492-497 [10.1097/QAI.0000000000000999].

Brief report: L-selectin (CD62L) is downregulated on CD4+ and CD8+ T lymphocytes of HIV-1-infected individuals naive for ART

BUONOMINI, ANNA RITA;Malagnino, V;ANDREONI, MASSIMO;
2016

Abstract

The expression of L-selectin (CD62L) in HIV-1 infection has not been extensively investigated. Here, we measured CD62L expression on T-cell subsets of HIV-1-infected individuals naive for antiretroviral therapy (ART-naive) or receiving therapy (ART), and seronegative control subjects (HIV-neg). We found reduced frequencies of CD62L cells among CD4 and CD8 T cells from ART-naive as compared with ART and HIV-neg groups, particularly within naive and central memory subsets. CD62L expression on T cells inversely correlated with viral load and rapidly increased after ART initiation. Plasma sCD62L levels did not correlate with CD62L expression, being higher in all HIV-1-infected individuals as compared with HIV-neg subjects. Finally, CD62L downregulation was found associated with the expression of the CD38 activation marker in CD8 T cells, but not in CD4 T cells. We suggest that CD62L downregulation due to unconstrained HIV-1 replication may have important consequences for T-cell circulation and function and for disease progression.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/17 - Malattie Infettive
English
CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Disease Progression; Gene Expression Profiling; HIV Infections; HIV-1; Humans; L-Selectin; Lymphocyte Activation; Receptor Cross-Talk; Viral Load; Virus Replication; Down-Regulation
Vassena, L., Giuliani, E., Buonomini, A.r., Malagnino, V., Andreoni, M., & Doria, M. (2016). Brief report: L-selectin (CD62L) is downregulated on CD4+ and CD8+ T lymphocytes of HIV-1-infected individuals naive for ART. JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 72(5), 492-497 [10.1097/QAI.0000000000000999].
Vassena, L; Giuliani, E; Buonomini, Ar; Malagnino, V; Andreoni, M; Doria, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/189195
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