The high potency and tolerability of the currently available antiretroviral drugs has modified HIV-1 infection from a life-threatening disease to a chronic illness. Nevertheless, some issues still remain open to optimize the management of HIV-1 infected patients in term of maintenance of virological suppression over time, identifying patients that could benefit from simplification therapy, and reducing co-mordibities driven by chronic inflammation. The availability of robust and affordable virological and immunological markers can help in solving these issues by providing information on the burden of HIV-1 reservoir in all the anatomical compartments in which the virus replicates as well as on persistent inflammation, immune activation and senescence despite successful virological suppression. In this light, this review is aimed at providing new insights (arising from a two-day Italian expert meeting hold in Rome in March 2016) in evaluation and monitoring of HIV-1 infection from a virological, immunological and clinical perspective. Particular attention has been focused on role of novel parameters (such as total HIV-1 DNA, residual viremia, and immunological markers) in optimizing treatment strategies, enhancing medical adherence, and individualizing monitoring.

Svicher, V., Marchetti, G., Ammassari, A., CECCHERINI SILBERSTEIN, F., Sarmati, L. (2017). Novelties in evaluation and monitoring of human immunodeficiency virus-1 infection: Is standard virological suppression enough for measuring antiretroviral treatment success?. AIDS REVIEWS, 19(3), 119-133 [10.24875/AIDSRev.M17000003].

Novelties in evaluation and monitoring of human immunodeficiency virus-1 infection: Is standard virological suppression enough for measuring antiretroviral treatment success?

SVICHER, VALENTINA;CECCHERINI SILBERSTEIN, FRANCESCA;SARMATI, LOREDANA
2017

Abstract

The high potency and tolerability of the currently available antiretroviral drugs has modified HIV-1 infection from a life-threatening disease to a chronic illness. Nevertheless, some issues still remain open to optimize the management of HIV-1 infected patients in term of maintenance of virological suppression over time, identifying patients that could benefit from simplification therapy, and reducing co-mordibities driven by chronic inflammation. The availability of robust and affordable virological and immunological markers can help in solving these issues by providing information on the burden of HIV-1 reservoir in all the anatomical compartments in which the virus replicates as well as on persistent inflammation, immune activation and senescence despite successful virological suppression. In this light, this review is aimed at providing new insights (arising from a two-day Italian expert meeting hold in Rome in March 2016) in evaluation and monitoring of HIV-1 infection from a virological, immunological and clinical perspective. Particular attention has been focused on role of novel parameters (such as total HIV-1 DNA, residual viremia, and immunological markers) in optimizing treatment strategies, enhancing medical adherence, and individualizing monitoring.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/17 - Malattie Infettive
English
Con Impact Factor ISI
Genotypic resistance testing; HIV-DNA; Immune-activation; Inflammation; Low level viremia; Residual viremia;
Svicher, V., Marchetti, G., Ammassari, A., CECCHERINI SILBERSTEIN, F., Sarmati, L. (2017). Novelties in evaluation and monitoring of human immunodeficiency virus-1 infection: Is standard virological suppression enough for measuring antiretroviral treatment success?. AIDS REVIEWS, 19(3), 119-133 [10.24875/AIDSRev.M17000003].
Svicher, V; Marchetti, G; Ammassari, A; CECCHERINI SILBERSTEIN, F; Sarmati, L
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/189091
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