The Golgi complex performs a central function in the secretory pathway in the sorting and sequential processing of a large number of proteins destined for other endomembrane organelles, the plasma membrane, or secretion from the cell, in addition to lipid metabolism and signaling. The Golgi apparatus can be regarded as a self-organizing system that maintains a relatively stable morphofunctional organization in the face of an enormous flux of lipids and proteins. A large number of the molecular players that operate in these processes have been identified, their functions and interactions defined, but there is still debate about many aspects that regulate protein trafficking and, in particular, the maintenance of these highly dynamic structures and processes. Here, we consider how an evolutionarily conserved underlying mechanism based on retrograde trafficking that uses lipids, COPI, SNAREs, and tethers could maintain such a homeodynamic system.

Wilson, C., Ragnini, A. (2010). Conserved molecular mechanisms underlying homeostasis of the Golgi complex. INTERNATIONAL JOURNAL OF CELL BIOLOGY, 2010(Article ID 758230), 758230 [10.1155/2010/758230].

Conserved molecular mechanisms underlying homeostasis of the Golgi complex

RAGNINI, ANTONELLA
2010-01-01

Abstract

The Golgi complex performs a central function in the secretory pathway in the sorting and sequential processing of a large number of proteins destined for other endomembrane organelles, the plasma membrane, or secretion from the cell, in addition to lipid metabolism and signaling. The Golgi apparatus can be regarded as a self-organizing system that maintains a relatively stable morphofunctional organization in the face of an enormous flux of lipids and proteins. A large number of the molecular players that operate in these processes have been identified, their functions and interactions defined, but there is still debate about many aspects that regulate protein trafficking and, in particular, the maintenance of these highly dynamic structures and processes. Here, we consider how an evolutionarily conserved underlying mechanism based on retrograde trafficking that uses lipids, COPI, SNAREs, and tethers could maintain such a homeodynamic system.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/10
English
Con Impact Factor ISI
intracellular traffic; Golgi,
Review
http://www.hindawi.com/journals/ijcb/2010/758230/
Wilson, C., Ragnini, A. (2010). Conserved molecular mechanisms underlying homeostasis of the Golgi complex. INTERNATIONAL JOURNAL OF CELL BIOLOGY, 2010(Article ID 758230), 758230 [10.1155/2010/758230].
Wilson, C; Ragnini, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/18869
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