Respiratory samples from Pneumocystis jirovecii pneumonia (PJP) cases collected at a tertiary-care university hospital in Modena were analyzed for the presence of specific polymorphisms in the mitochondrial large subunit ribosomal RNA (mtLSU-rRNA). Retrospectively, 57 cases were selected in a six-year period and 34 out of the 57 processed BAL samples returned PCR positive results, thus allowing further molecular analysis. The following P.jirovecii genotype distribution was observed: genotype 3 (50%), genotype 2 (23%), genotype 1 (18%), genotypes 1 or 4 (9%). These data add novel insights on P.jirovecii epidemiology, investigating a previously unstudied area of Northern Italy. A peculiar local distribution is highlighted with respect to other areas within the national panorama, thus encouraging further in-depth studies in an attempt to better understand the overall situation concerning P.jirovecii genotype circulation.

Pini, P., Orsi, C., La Regina, A., Peppoloni, S., Berrilli, F., Blasi, E., et al. (2017). Pneumocystis jirovecii genotyping: experience in a tertiary-care hospital in Northern Italy. NEW MICROBIOLOGICA, 40(3), 208-211.

Pneumocystis jirovecii genotyping: experience in a tertiary-care hospital in Northern Italy

BERRILLI, FEDERICA;DI CAVE, DAVID
2017-07-01

Abstract

Respiratory samples from Pneumocystis jirovecii pneumonia (PJP) cases collected at a tertiary-care university hospital in Modena were analyzed for the presence of specific polymorphisms in the mitochondrial large subunit ribosomal RNA (mtLSU-rRNA). Retrospectively, 57 cases were selected in a six-year period and 34 out of the 57 processed BAL samples returned PCR positive results, thus allowing further molecular analysis. The following P.jirovecii genotype distribution was observed: genotype 3 (50%), genotype 2 (23%), genotype 1 (18%), genotypes 1 or 4 (9%). These data add novel insights on P.jirovecii epidemiology, investigating a previously unstudied area of Northern Italy. A peculiar local distribution is highlighted with respect to other areas within the national panorama, thus encouraging further in-depth studies in an attempt to better understand the overall situation concerning P.jirovecii genotype circulation.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore VET/06 - Parassitologia e Malattie Parassitarie degli Animali
English
Pneumocystis jirovecii; genotyping; pneumonia
Pini, P., Orsi, C., La Regina, A., Peppoloni, S., Berrilli, F., Blasi, E., et al. (2017). Pneumocystis jirovecii genotyping: experience in a tertiary-care hospital in Northern Italy. NEW MICROBIOLOGICA, 40(3), 208-211.
Pini, P; Orsi, C; La Regina, A; Peppoloni, S; Berrilli, F; Blasi, E; DI CAVE, D
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/188679
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