HIV protease inhibitors have been shown to exert antiangiogenic and antitumor actions independently from their antiretroviral effect. Based on these studies, HIV-seronegative patients with classic Kaposi's sarcoma were treated with indinavir and followed for clinical evolution, drug pharmacokinetics and Kaposi's sarcoma biomarkers. A favorable clinical course was associated with high drug plasma levels, reduced production of basic fibroblast growth factor, lower numbers of circulating endothelial cells, and a decrease in antibody titers against human herpesvirus 8.

Monini, P., Sgadari, C., Grosso, M., Bellino, S., Di Biagio, A., Toschi, E., et al. (2009). Clinical course of classic Kaposi's sarcoma in HIV-negative patients treated with the HIV protease inhibitor indinavir. AIDS, 23(4), 534-538 [10.1097/QAD.0b013e3283262a8d].

Clinical course of classic Kaposi's sarcoma in HIV-negative patients treated with the HIV protease inhibitor indinavir

BARILLARI, GIOVANNI;SARMATI, LOREDANA;ANDREONI, MASSIMO;
2009-01-01

Abstract

HIV protease inhibitors have been shown to exert antiangiogenic and antitumor actions independently from their antiretroviral effect. Based on these studies, HIV-seronegative patients with classic Kaposi's sarcoma were treated with indinavir and followed for clinical evolution, drug pharmacokinetics and Kaposi's sarcoma biomarkers. A favorable clinical course was associated with high drug plasma levels, reduced production of basic fibroblast growth factor, lower numbers of circulating endothelial cells, and a decrease in antibody titers against human herpesvirus 8.
2009
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/09 - MEDICINA INTERNA
Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA
Settore MED/17 - MALATTIE INFETTIVE
English
Con Impact Factor ISI
Aged; Aged, 80 and over; Antibodies, Viral; Antineoplastic Agents; Biomarkers, Tumor; HIV Protease Inhibitors; HIV Seronegativity; Herpesvirus 8, Human; Humans; Indinavir; Middle Aged; Sarcoma, Kaposi; Treatment Outcome
Monini, P., Sgadari, C., Grosso, M., Bellino, S., Di Biagio, A., Toschi, E., et al. (2009). Clinical course of classic Kaposi's sarcoma in HIV-negative patients treated with the HIV protease inhibitor indinavir. AIDS, 23(4), 534-538 [10.1097/QAD.0b013e3283262a8d].
Monini, P; Sgadari, C; Grosso, M; Bellino, S; Di Biagio, A; Toschi, E; Bacigalupo, I; Sabbatucci, M; Cencioni, G; Salvi, E; Leone, P; Ensoli, B; Baril...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/188660
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