In the past, the study of KS pathogenesis has been hampered by the lack of in vitro and in vivo experimental systems. Recently, the establishment of long-term cultures of KS spindle cells and the development of animal models have allowed a variety of studies on the pathobiology of the disease. The results from these studies, reviewed herein, indicate that KS is a cytokine-mediated disease and that inflammatory and angiogenic cytokines and the HIV-1 Tat protein cooperate in its induction and progression in HIV-1-infected individuals.
Ensoli, B., Barillari, G., Gallo, R. (1992). Cytokines and growth factors in the pathogenesis of AIDS-associated Kaposi's sarcoma. IMMUNOLOGICAL REVIEWS, 127, 147-155 [10.1111/j.1600-065X.1992.tb01412.x].
Cytokines and growth factors in the pathogenesis of AIDS-associated Kaposi's sarcoma
BARILLARI, GIOVANNI;
1992-06-01
Abstract
In the past, the study of KS pathogenesis has been hampered by the lack of in vitro and in vivo experimental systems. Recently, the establishment of long-term cultures of KS spindle cells and the development of animal models have allowed a variety of studies on the pathobiology of the disease. The results from these studies, reviewed herein, indicate that KS is a cytokine-mediated disease and that inflammatory and angiogenic cytokines and the HIV-1 Tat protein cooperate in its induction and progression in HIV-1-infected individuals.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
