In the past, the study of KS pathogenesis has been hampered by the lack of in vitro and in vivo experimental systems. Recently, the establishment of long-term cultures of KS spindle cells and the development of animal models have allowed a variety of studies on the pathobiology of the disease. The results from these studies, reviewed herein, indicate that KS is a cytokine-mediated disease and that inflammatory and angiogenic cytokines and the HIV-1 Tat protein cooperate in its induction and progression in HIV-1-infected individuals.

Ensoli, B., Barillari, G., Gallo, R. (1992). Cytokines and growth factors in the pathogenesis of AIDS-associated Kaposi's sarcoma. IMMUNOLOGICAL REVIEWS, 127, 147-155 [10.1111/j.1600-065X.1992.tb01412.x].

Cytokines and growth factors in the pathogenesis of AIDS-associated Kaposi's sarcoma

BARILLARI, GIOVANNI;
1992

Abstract

In the past, the study of KS pathogenesis has been hampered by the lack of in vitro and in vivo experimental systems. Recently, the establishment of long-term cultures of KS spindle cells and the development of animal models have allowed a variety of studies on the pathobiology of the disease. The results from these studies, reviewed herein, indicate that KS is a cytokine-mediated disease and that inflammatory and angiogenic cytokines and the HIV-1 Tat protein cooperate in its induction and progression in HIV-1-infected individuals.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/05 - Patologia Clinica
English
Con Impact Factor ISI
Acquired Immunodeficiency Syndrome; Animals; Cytokines; Disease Models, Animal; Genes, tat; Growth Substances; HIV Infections; HIV-1; Humans; Sarcoma, Kaposi; Tumor Cells, Cultured
Ensoli, B., Barillari, G., Gallo, R. (1992). Cytokines and growth factors in the pathogenesis of AIDS-associated Kaposi's sarcoma. IMMUNOLOGICAL REVIEWS, 127, 147-155 [10.1111/j.1600-065X.1992.tb01412.x].
Ensoli, B; Barillari, G; Gallo, R
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/188635
Citazioni
  • ???jsp.display-item.citation.pmc??? 42
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 135
social impact