The aim of this study was to define the clinical impact of Herpes simplex virus-1 (HSV-1) DNA detection in the low respiratory tract of hospitalized patients. Forty-nine patients admitted to the University Hospital Tor Vergata, Rome, Italy, from May 2013 to June 2014, were analysed. Inclusion criteria were the presence or absence of HSV-1 DNA in clinical routine bronchoalveolar lavage (BAL) fluid specimens. Nineteen individuals were positive (cases) and 30 negative (controls) for the presence of HSV-1 DNA. The two groups were matched for age, gender and month of BAL collection. Cases and controls differed significantly according to length of stay in hospital (p=0.027), ICU transfer (p=0.02), disease severity (p=0.003), death (p=0.009), haematological and blood chemistry tests. Among cases, survivors and deceased patients differed significantly regarding ICU transfer (p=0.0001), mechanical ventilation (p=0.0048), disease severity (p=0.028) and risk of death (p=0.013). A trend towards higher HSV-1 loads was observed in the cases who died. These results suggest that detection of HSV-1 DNA in BAL fluid specimens is a marker of disease severity and poor outcome. Further prospective studies are necessary to deepen the clinical significance of HSV-1 DNA detection in the lower respiratory tract of hospitalized patients.
Pica, F., Ciotti, M., Maurici, M., Buè, C., Nardi, P., Lucà, G., et al. (2017). Clinical features and outcome of hospitalized patients with HSV-1 DNA in the lower respiratory tract. NEW MICROBIOLOGICA, 40(2), 107-112.
|Tipologia:||Articolo su rivista|
|Citazione:||Pica, F., Ciotti, M., Maurici, M., Buè, C., Nardi, P., Lucà, G., et al. (2017). Clinical features and outcome of hospitalized patients with HSV-1 DNA in the lower respiratory tract. NEW MICROBIOLOGICA, 40(2), 107-112.|
|IF:||Con Impact Factor ISI|
|Settore Scientifico Disciplinare:||Settore MED/10 - Malattie dell'Apparato Respiratorio|
Settore MED/17 - Malattie Infettive
Settore MED/07 - Microbiologia e Microbiologia Clinica
|Revisione (peer review):||Esperti anonimi|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||apr-2017|
|Titolo:||Clinical features and outcome of hospitalized patients with HSV-1 DNA in the lower respiratory tract|
|Autori:||Pica, F; Ciotti, M; Maurici, M; Buè, C; Nardi, P; Lucà, G; Moroni, G; Rogliani, P; Perno, Cf; Volpi, A|
|Appare nelle tipologie:||01 - Articolo su rivista|