Recently, interest for the potential impact of consumer-relevant engineered nanoparticles on pregnancy has dramatically increased. This study investigates whether inhaled silver nanoparticles (AgNPs) reach and cross mouse placental barrier and induce adverse effects. Apart from their relevance for the growing use in consumer products and biomedical applications, AgNPs are selected since they can be unequivocally identified in tissues. Pregnant mouse females are exposed during the first 15 days of gestation by nose-only inhalation to a freshly produced aerosol of 18-20 nm AgNPs for either 1 or 4 hours, at a particle number concentration of 3.80 × 107 part. cm(-3) and at a mass concentration of 640 µg/m³. AgNPs are identified and quantitated in maternal tissues, placentas and foetuses by Transmission Electron Microscopy coupled with Energy-dispersive X-ray spectroscopy and single-particle Inductively Coupled Plasma Mass Spectrometry. Inhalation of AgNPs results in increased number of resorbed foetuses, associated to reduced oestrogen plasma levels, in the 4h/day exposed mothers. Increased expression of pregnancy-relevant inflammatory cytokines is also detected in the placentas of both groups. These results proof that NPs are able to reach and cross the mouse placenta, and suggest that precaution should be taken with respect to acute exposure to nanoparticles during pregnancy.
Campagnolo, L., Massimiani, M., Vecchione, L., Piccirilli, D., Toschi, N., Magrini, A., et al. (2017). Silver Nanoparticles Inhaled during Pregnancy Reach and Affect the Placenta and the Foetus. NANOTOXICOLOGY, 1-36.
|Tipologia:||Articolo su rivista|
|Citazione:||Campagnolo, L., Massimiani, M., Vecchione, L., Piccirilli, D., Toschi, N., Magrini, A., et al. (2017). Silver Nanoparticles Inhaled during Pregnancy Reach and Affect the Placenta and the Foetus. NANOTOXICOLOGY, 1-36.|
|Settore Scientifico Disciplinare:||Settore BIO/17|
|Revisione (peer review):||Sì, ma tipo non specificato|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1080/17435390.2017.1343875|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||16-giu-2017|
|Titolo:||Silver Nanoparticles Inhaled during Pregnancy Reach and Affect the Placenta and the Foetus|
|Autori:||Campagnolo, L; Massimiani, M; Vecchione, L; Piccirilli, D; Toschi, N; Magrini, A; Bonanno, E; Scimeca, M; Castagnozzi, L; Buonanno, G; Stabile, L; Cubadda, F; Aureli, F; Fokkens, P; Kreyling, W; Cassee, F; Pietroiusti, A|
|Appare nelle tipologie:||01 - Articolo su rivista|