The Multiple Sclerosis (MS) diagnosis is based on dissemination of focal lesions in time and space. The free light chains (FLCs) determination might be a sensitive alternative to oligoclonal bands assay. The study aim was to redefine sensitivity, specificity of the kFLC Index cut-off. We analyzed serum and cerebrospinal fluid of 176 patients, with different neurological disorders. We obtained a cut off of 12,3 for kFLC Index with a sensitivity and specificity of 93% and 100% respectively. Our data confirm that the kFLC Index is a valid tool in the diagnosis of MS.
Pieri, M., Storto, M., Pignalosa, S., Zenobi, R., Buttari, F., Bernardini, S., et al. (2017). KFLC Index utility in multiple sclerosis diagnosis: Further confirmation. JOURNAL OF NEUROIMMUNOLOGY, 309, 31-33 [10.1016/j.jneuroim.2017.05.007].
KFLC Index utility in multiple sclerosis diagnosis: Further confirmation
PIERI, MASSIMO;ZENOBI, ROSSELLA;BERNARDINI, SERGIO;CENTONZE, DIEGO;DESSI', MARIARITA
2017-08-15
Abstract
The Multiple Sclerosis (MS) diagnosis is based on dissemination of focal lesions in time and space. The free light chains (FLCs) determination might be a sensitive alternative to oligoclonal bands assay. The study aim was to redefine sensitivity, specificity of the kFLC Index cut-off. We analyzed serum and cerebrospinal fluid of 176 patients, with different neurological disorders. We obtained a cut off of 12,3 for kFLC Index with a sensitivity and specificity of 93% and 100% respectively. Our data confirm that the kFLC Index is a valid tool in the diagnosis of MS.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
